化学基因组学：利用非甾体糖皮质激素受体调节剂精确调控转录网络

Chemical genomics: dialed in transcriptional network control with non-steroidal glucocorticoid receptor modulators.

作者信息

Allen Jasmina J, Shokat Kevan M

机构信息

University of California-San Fransisco, 600 16th Street, GH-N512D, San Francisco, California 94143, USA.

出版信息

ACS Chem Biol. 2006 Apr 25;1(3):139-40. doi: 10.1021/cb600137r.

DOI:10.1021/cb600137r

PMID:17163659

Abstract

A recent study analyzed the transcriptional effects induced by a panel of non-steroidal glucocorticoid receptor modulators. The authors discover patterns of cell-, gene-, and mechanism-specific regulation, with implications for development of improved anti-inflammatory agents.

摘要

最近一项研究分析了一组非甾体糖皮质激素受体调节剂所诱导的转录效应。作者发现了细胞、基因和机制特异性调控模式，这对开发改进的抗炎药物具有启示意义。