Nielsen Jørn Dalsgaard, Rasmussen Hans Morten Schnack, Husted Steen Elkjaer
Amtssygehuset i Gentofte, Trombosecentret, Klinisk-biokemisk Afdeling, H:S Bispebjerg Hospital, Hellerup.
Ugeskr Laeger. 2006 Dec 4;168(49):4296-9.
Management of perioperative treatment with anticoagulants and antiplatelet drugs is a complex medical problem. Careful preoperative evaluation of the risk of bleeding and thromboembolism with and without of antithrombotic therapy is the key prerequisite to secure safe outcome of elective, invasive procedures performed on patients treated with antithrombotic agents. In emergency cases, knowledge of the pharmacokinetics and pharmacodynamics of antithrombotic drugs and of the effect of antidotes and blood-derived, recombinant, and other haemostatic products is important.
围手术期抗凝剂和抗血小板药物的治疗管理是一个复杂的医学问题。在有或没有抗血栓治疗的情况下,仔细进行术前出血和血栓栓塞风险评估是确保接受抗血栓药物治疗的患者进行择期侵入性手术获得安全结果的关键前提。在紧急情况下,了解抗血栓药物的药代动力学和药效学以及解毒剂和血液来源、重组及其他止血产品的作用非常重要。