Pautrat Karine, Bretagnol Frederic, Huten Noel, de Calan Loic
Department of Digestive Surgery, Trousseau Hospital, Tours, France.
Dis Colon Rectum. 2007 Apr;50(4):472-7. doi: 10.1007/s10350-006-0787-8.
The natural history of sigmoid diverticulitis in terms of the virulence and management in young patients is an ongoing controversy. This retrospective study was designed to assess the severity and early management of acute diverticulitis according to age.
From 2000 to 2004, 284 patients were admitted for acute diverticulitis. Fifty-two patients (18 percent) were aged 50 years or younger and were divided in two groups: aged 40 years or younger (Group 1, n = 20), and patients older than aged 40 years (Group 2, n = 32). The diagnosis was confirmed by computed tomography in 49 patients (94 percent).
Radiologic findings showed that the rate of complicated lesions (i.e., diverticular perforation and/or abscess) was significantly higher for patients younger than aged 40 years than patients older, respectively 72 and 35 percent (P = 0.02). The risk of requiring immediate surgical treatment was significantly more frequent in Group 1 than Group 2 (40 vs.13 percent; P = 0.04). There was a trend toward a higher risk of "major surgery" (i.e., Hartmann's procedure) in Group 1 than Group 2 (15 vs. 0 percent; P = 0.05).
Diverticulitis in patients younger than aged 40 years seems to have a particularly aggressive and fulminant course and requires early surgical procedures for complications (associated abscess, colonic perforation) in 40 percent of cases. The use of "major procedure" (i.e., stoma) is more frequent in these patients.
关于年轻患者乙状结肠憩室炎的毒力及治疗方面的自然病史一直存在争议。本回顾性研究旨在根据年龄评估急性憩室炎的严重程度及早期治疗情况。
2000年至2004年期间,284例患者因急性憩室炎入院。52例患者(18%)年龄在50岁及以下,分为两组:40岁及以下(第1组,n = 20),以及40岁以上患者(第2组,n = 32)。49例患者(94%)通过计算机断层扫描确诊。
影像学检查结果显示,40岁以下患者复杂病变(即憩室穿孔和/或脓肿)的发生率显著高于40岁以上患者,分别为72%和35%(P = 0.02)。第1组患者需要立即进行手术治疗的风险显著高于第2组(40%对13%;P = 0.04)。第1组进行“大手术”(即Hartmann手术)的风险有高于第2组的趋势(15%对0%;P = 0.05)。
40岁以下患者的憩室炎似乎具有特别侵袭性和暴发性的病程,40%的病例因并发症(相关脓肿、结肠穿孔)需要早期手术治疗。这些患者更频繁地使用“大手术”(即造口术)。