Newcombe D S, Ciosek C P, Ishikawa Y, Fahey J V
Proc Natl Acad Sci U S A. 1975 Aug;72(8):3124-8. doi: 10.1073/pnas.72.8.3124.
The human synoviocyte increases its intracellular adenosine 3':5'-cyclic monophosphate (cAMP) concentration significantly after incubation with prostaglandin E1, prostaglandin E2, or l-epinephrine. The cells can be desensitized to these same hormones. Hormone-induced desensitization is receptor site specific and associated with a significant increase in intracellular 3':5'-cyclic AMP phosphodiesterase (EC 3.1.4. 17; 3':5'-cyclic AMP 5'-nucleotidohydrolase) activity, whereas cAMP-induced desensitization is not hormone specific.
人滑膜细胞在与前列腺素E1、前列腺素E2或l-肾上腺素孵育后,其细胞内3':5'-环磷酸腺苷(cAMP)浓度显著增加。这些细胞可对这些相同的激素产生脱敏作用。激素诱导的脱敏作用具有受体位点特异性,并与细胞内3':5'-环磷酸腺苷磷酸二酯酶(EC 3.1.4.17;3':5'-环磷酸腺苷5'-核苷酸水解酶)活性的显著增加相关,而cAMP诱导的脱敏作用并非激素特异性的。