人滑膜细胞：前列腺素和1-肾上腺素的激活与脱敏作用
Human synoviocytes: activation and desensitization by prostaglandins and 1-epinephrine.
作者信息
Newcombe D S, Ciosek C P, Ishikawa Y, Fahey J V
出版信息
Proc Natl Acad Sci U S A. 1975 Aug;72(8):3124-8. doi: 10.1073/pnas.72.8.3124.
Abstract
The human synoviocyte increases its intracellular adenosine 3':5'-cyclic monophosphate (cAMP) concentration significantly after incubation with prostaglandin E1, prostaglandin E2, or l-epinephrine. The cells can be desensitized to these same hormones. Hormone-induced desensitization is receptor site specific and associated with a significant increase in intracellular 3':5'-cyclic AMP phosphodiesterase (EC 3.1.4. 17; 3':5'-cyclic AMP 5'-nucleotidohydrolase) activity, whereas cAMP-induced desensitization is not hormone specific.
摘要
人滑膜细胞在与前列腺素E1、前列腺素E2或l-肾上腺素孵育后，其细胞内3':5'-环磷酸腺苷（cAMP）浓度显著增加。这些细胞可对这些相同的激素产生脱敏作用。激素诱导的脱敏作用具有受体位点特异性，并与细胞内3':5'-环磷酸腺苷磷酸二酯酶（EC 3.1.4.17；3':5'-环磷酸腺苷5'-核苷酸水解酶）活性的显著增加相关，而cAMP诱导的脱敏作用并非激素特异性的。
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