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人滑膜细胞：前列腺素和1-肾上腺素的激活与脱敏作用

Human synoviocytes: activation and desensitization by prostaglandins and 1-epinephrine.

作者信息

Newcombe D S, Ciosek C P, Ishikawa Y, Fahey J V

出版信息

Proc Natl Acad Sci U S A. 1975 Aug;72(8):3124-8. doi: 10.1073/pnas.72.8.3124.

DOI:10.1073/pnas.72.8.3124
PMID:171653
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC432933/
Abstract

The human synoviocyte increases its intracellular adenosine 3':5'-cyclic monophosphate (cAMP) concentration significantly after incubation with prostaglandin E1, prostaglandin E2, or l-epinephrine. The cells can be desensitized to these same hormones. Hormone-induced desensitization is receptor site specific and associated with a significant increase in intracellular 3':5'-cyclic AMP phosphodiesterase (EC 3.1.4. 17; 3':5'-cyclic AMP 5'-nucleotidohydrolase) activity, whereas cAMP-induced desensitization is not hormone specific.

摘要

人滑膜细胞在与前列腺素E1、前列腺素E2或l-肾上腺素孵育后，其细胞内3':5'-环磷酸腺苷（cAMP）浓度显著增加。这些细胞可对这些相同的激素产生脱敏作用。激素诱导的脱敏作用具有受体位点特异性，并与细胞内3':5'-环磷酸腺苷磷酸二酯酶（EC 3.1.4.17；3':5'-环磷酸腺苷5'-核苷酸水解酶）活性的显著增加相关，而cAMP诱导的脱敏作用并非激素特异性的。

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本文引用的文献

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Indomethacin potentiates PGE1 stimulated cyclic AMP accumulation in human synoviocytes.吲哚美辛增强前列腺素E1刺激的人滑膜细胞中环磷酸腺苷的积累。
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Hormone-induced desensitisation of hormonal control of cyclic AMP levels in human diploid fibroblasts.激素诱导人二倍体成纤维细胞中环磷酸腺苷水平激素控制的脱敏作用。
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Cyclic AMP levels in fibroblasts: relationship to growth rate and contact inhibition of growth.成纤维细胞中环磷酸腺苷水平：与生长速率及生长接触抑制的关系
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