佛波醇酯A的全合成。1. 四个亚基的制备。

Total synthesis of phorboxazole a. 1. Preparation of four subunits.

作者信息

White James D, Kuntiyong Punlop, Lee Tae Hee

机构信息

Department of Chemistry, Oregon State University, Corvallis, Oregon 97331, USA.

出版信息

Org Lett. 2006 Dec 21;8(26):6039-42. doi: 10.1021/ol062530r.

DOI:10.1021/ol062530r

PMID:17165924

Abstract

[Structure: see text] Four subunits of the potent antitumor agent phorboxazole A were constructed; fragments C20-C32 and C9-C19 containing tetrahydropyrans A and B, respectively, were assembled using palladium-catalyzed intramolecular alkoxycarbonylation.

摘要

[结构：见正文] 构建了强效抗肿瘤药物佛波醇酯A的四个亚基；分别含有四氢吡喃A和B的片段C20-C32和C9-C19，通过钯催化的分子内烷氧基羰基化反应进行组装。