利用烟碱抗炎途径治疗上皮炎症性疾病。
Exploitation of the nicotinic anti-inflammatory pathway for the treatment of epithelial inflammatory diseases.
作者信息
Scott David A, Martin Michael
机构信息
Oral Health and Systemic Disease Research Group, Department of Pharmacology and Toxicology, University of Louisville School of Dentistry, 501 South Preston Street, Louisville, KY 40292, United States.
出版信息
World J Gastroenterol. 2006 Dec 14;12(46):7451-9. doi: 10.3748/wjg.v12.i46.7451.
Abstract
Discoveries in the first few years of the 21st century have led to an understanding of important interactions between the nervous system and the inflammatory response at the molecular level, most notably the acetylcholine (ACh)-triggered, alpha7-nicotinic acetylcholine receptor (alpha7nAChR)-dependent nicotinic anti-inflammatory pathway. Studies using the alpha7nAChR agonist, nicotine, for the treatment of mucosal inflammation have been undertaken but the efficacy of nicotine as a treatment for inflammatory bowel diseases remains debatable. Further understanding of the nicotinic anti-inflammatory pathway and other endogenous anti-inflammatory mechanisms is required in order to develop refined and specific therapeutic strategies for the treatment of a number of inflammatory diseases and conditions, including periodontitis, psoriasis, sarcoidosis, and ulcerative colitis.
摘要
21世纪头几年的发现使人们在分子水平上对神经系统与炎症反应之间的重要相互作用有了认识，最显著的是乙酰胆碱（ACh）触发的、α7烟碱型乙酰胆碱受体（α7nAChR）依赖性烟碱抗炎途径。已经开展了使用α7nAChR激动剂尼古丁治疗黏膜炎症的研究，但尼古丁作为炎症性肠病治疗药物的疗效仍存在争议。为了开发针对包括牙周炎、银屑病、结节病和溃疡性结肠炎在内的多种炎症性疾病和病症的精确且特异性的治疗策略，需要进一步了解烟碱抗炎途径和其他内源性抗炎机制。
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