Toll样受体2和4在牙龈炎和慢性牙周炎中的表达
Expression of Toll-like receptors 2 and 4 in gingivitis and chronic periodontitis.
作者信息
Sarah S M, Tamilselvan S, Kamatchiammal S, Suresh R
机构信息
Department of Periodontics, Sri Ramachandra Medical College & Research Institute, Porur, Chenai.
出版信息
Indian J Dent Res. 2006 Jul-Sep;17(3):114-6. doi: 10.4103/0970-9290.29879.
Periodontal disease is the major cause of adult tooth loss and is commonly characterized by a chronic inflammation caused by infection by oral bacteria. Members of Toll-like receptor (TLR) family recognize conserved microbial structures, such as bacterial lipopolysaccharides, and activate signaling pathways that result in immune responses against microbial infections. The aim of the present study was to assess the mRNA expression of TLR-2 and TLR-4 in gingivitis and chronic periodontitis. Gingival tissue samples were collected from patients with chronic periodontitis, gingivitis, and healthy controls. Total RNA was extracted and RT-PCR was done for TLR-2 and TLR-4. The results showed that TLR-2 was significantly increased in gingivitis compared to TLR-4 expression and decreased in chronic periodontitis.
牙周病是成人牙齿脱落的主要原因，其通常特征为由口腔细菌感染引起的慢性炎症。Toll样受体（TLR）家族成员识别保守的微生物结构，如细菌脂多糖，并激活导致针对微生物感染的免疫反应的信号通路。本研究的目的是评估TLR-2和TLR-4在牙龈炎和慢性牙周炎中的mRNA表达。从慢性牙周炎患者、牙龈炎患者和健康对照中收集牙龈组织样本。提取总RNA并对TLR-2和TLR-4进行逆转录聚合酶链反应（RT-PCR）。结果显示，与TLR-4表达相比，TLR-2在牙龈炎中显著增加，而在慢性牙周炎中降低。
Zotero 插件