作为细胞周期蛋白依赖性激酶抑制剂的3-羟基色酮：合成与生物学评价
3-Hydroxychromones as cyclin-dependent kinase inhibitors: synthesis and biological evaluation.
作者信息
Lee Jinho, Park Taesik, Jeong Shinwu, Kim Kyoung-Hee, Hong Changyong
机构信息
Department of Chemistry, Keimyung University, 1000 Sindang-Dong, Dalseo-Gu, Daegu 704-701, South Korea.
出版信息
Bioorg Med Chem Lett. 2007 Mar 1;17(5):1284-7. doi: 10.1016/j.bmcl.2006.12.011. Epub 2006 Dec 15.
PMID:17178224
Abstract
A novel series of 3-hydroxychromones were prepared and found to be CDK inhibitors. Isothiazolidine 1,1-dioxide analogues showed potent CDK1 and CDK2 inhibitory activities and inhibited proliferation of EJ, HCT116, SW620, and MDAMB468 cancer cells.
摘要
制备了一系列新型的3-羟基色酮，并发现它们是细胞周期蛋白依赖性激酶（CDK）抑制剂。异噻唑烷1,1-二氧化物类似物表现出强效的CDK1和CDK2抑制活性，并抑制EJ、HCT116、SW620和MDAMB468癌细胞的增殖。
Zotero 插件