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Heart rate reduction by inhibition of If or by beta-blockade has different effects on postsystolic wall thickening.
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Heart rate reduction during exercise-induced myocardial ischaemia and stunning.
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Effect of graded heart rate reduction with ivabradine on myocardial oxygen consumption and diastolic time in exercising dogs.
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Differential effects of heart rate reduction and beta-blockade on left ventricular relaxation during exercise.
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Chronic heart rate reduction facilitates cardiomyocyte survival after myocardial infarction.
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Effect of metoprolol and ivabradine on left ventricular remodelling and Ca2+ handling in the post-infarction rat heart.
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Ivabradine, coronary artery disease, and heart failure: beyond rhythm control.
Drug Des Devel Ther. 2014 Jun 3;8:689-700. doi: 10.2147/DDDT.S60591. eCollection 2014.
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Heart rate: a forgotten link in coronary artery disease?
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Heart rate in the pathophysiology of coronary blood flow and myocardial ischaemia: benefit from selective bradycardic agents.
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Preclinical results with I(f) current inhibition by ivabradine.
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1
Drug insight: If inhibitors as specific heart-rate-reducing agents.
Nat Clin Pract Cardiovasc Med. 2004 Dec;1(2):103-9. doi: 10.1038/ncpcardio0052.
2
Rapid ventricular pacing induces delayed cardioprotection against myocardial stunning.
J Mol Cell Cardiol. 2005 Dec;39(6):849-55. doi: 10.1016/j.yjmcc.2005.03.024. Epub 2005 Oct 19.
3
Efficacy of ivabradine, a new selective I(f) inhibitor, compared with atenolol in patients with chronic stable angina.
Eur Heart J. 2005 Dec;26(23):2529-36. doi: 10.1093/eurheartj/ehi586. Epub 2005 Oct 7.
4
Do regional deformation indexes reflect regional perfusion in all ischemic substrates?
J Am Coll Cardiol. 2004 Oct 19;44(8):1672-4. doi: 10.1016/j.jacc.2004.07.024.
5
Distinctive changes in end-diastolic wall thickness and postsystolic thickening in viable and infarcted myocardium.
J Am Soc Echocardiogr. 2004 Aug;17(8):855-62. doi: 10.1016/j.echo.2004.04.038.
7
Heart rate reduction during exercise-induced myocardial ischaemia and stunning.
Eur Heart J. 2004 Apr;25(7):579-86. doi: 10.1016/j.ehj.2003.10.010.
9
Timing of cardiac contraction in humans mapped by high-temporal-resolution MRI tagging: early onset and late peak of shortening in lateral wall.
Am J Physiol Heart Circ Physiol. 2004 May;286(5):H1872-80. doi: 10.1152/ajpheart.01047.2003. Epub 2004 Jan 15.
10
Anti-ischemic effects of ivabradine, a selective heart rate-reducing agent, in exercise-induced myocardial ischemia in pigs.
J Cardiovasc Pharmacol. 2003 Nov;42(5):688-96. doi: 10.1097/00005344-200311000-00016.

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