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[体重、营养因素与身体活动——它们对乳腺癌诊断后预后的影响]

[Body weight, nutritional factors and physical activity--their influence on prognosis after breast cancer diagnosis].

作者信息

Weitzen Rony, Tichler Thomas, Kaufman Bella, Catane Raphael, Shpatz Yael

机构信息

The Oncology Institute, Sheba Medical Center, Tel Hashomer, Israel.

出版信息

Harefuah. 2006 Nov;145(11):820-5, 861.

Abstract

Numerous studies have examined the association between body weight, nutritional factors, physical activity and the risk for primary breast cancer. Relatively few studies, however, have examined the associations between these issues and the recurrence of the disease and cure of the primary tumor. Today, three areas of focus are actively being researched for breast cancer survivors: body weight, diet composition and physical activity with specific emphasis on the risk for recurrence, survival and quality of life. Increased body weight or BMI (Body Mass Index) at diagnosis was found to be a significant risk factor for recurrent disease, decreased survival, or both. Overall obesity has been shown to adversely affect prognosis. Appropriate weight control may be particularly beneficial for breast cancer survivors. Breast cancer survivors should be encouraged to achieve and maintain a healthy weight. Limiting fat intake can reduce the risk of breast cancer recurrence. Increasing consumption of vegetables and fruits seems to have possible beneficial effects during and after treatments. To date physical activity after breast cancer diagnosis has been found to reduce the risk of death. The greatest benefit occurred in women who performed the equivalent of walking 3-5 hours per week at an average pace. Safe weight loss via increased physical activity and healthful food choices should be encouraged for normal, overweight or obese breast cancer survivors in order to improve survival and life quality.

摘要

众多研究探讨了体重、营养因素、身体活动与原发性乳腺癌风险之间的关联。然而,相对较少的研究考察了这些因素与疾病复发及原发性肿瘤治愈之间的关系。如今,针对乳腺癌幸存者有三个重点研究领域:体重、饮食构成和身体活动,特别关注复发风险、生存率及生活质量。研究发现,诊断时体重增加或身体质量指数(BMI)升高是疾病复发、生存率降低的重要风险因素,或两者皆有。总体肥胖已被证明会对预后产生不利影响。适当控制体重对乳腺癌幸存者可能尤为有益。应鼓励乳腺癌幸存者达到并维持健康体重。限制脂肪摄入可降低乳腺癌复发风险。增加蔬菜和水果的摄入量在治疗期间及治疗后似乎可能有有益影响。迄今为止,已发现乳腺癌诊断后进行身体活动可降低死亡风险。最大的益处出现在每周以平均速度步行3至5小时的女性身上。对于正常体重、超重或肥胖的乳腺癌幸存者,应鼓励通过增加身体活动和选择健康食物来安全减重,以提高生存率和生活质量。

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