钙蛋白酶II免疫反应性在阿尔茨海默病老年斑中的存在情况。
Presence of calpain II immunoreactivity in senile plaques in Alzheimer's disease.
作者信息
Shimohama S, Suenaga T, Araki W, Yamaoaka Y, Shimizu K, Kimura J
机构信息
Department of Neurology, Faculty of Medicine, Kyoto University, Japan.
出版信息
Brain Res. 1991 Aug 30;558(1):105-8. doi: 10.1016/0006-8993(91)90722-8.
Calpains are calcium-dependent neutral cysteine proteinases. We utilized a specific anti-calpain II antibody to examine immunohistochemically whether calpain II is associated with pathological changes in Alzheimer's disease (AD). Calpain II was mainly expressed in the neurons in control human brains. In AD brains, intense immunoreactivity was present in the dystrophic neurites of senile plaques. These results suggest that calpain II is involved in the pathogenesis of AD.
钙蛋白酶是钙依赖性中性半胱氨酸蛋白酶。我们使用一种特异性抗钙蛋白酶II抗体，通过免疫组织化学方法检测钙蛋白酶II是否与阿尔茨海默病（AD）的病理变化相关。钙蛋白酶II主要在对照人脑的神经元中表达。在AD脑中，老年斑的营养不良性神经突中存在强烈的免疫反应性。这些结果表明钙蛋白酶II参与了AD的发病机制。
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