Hansen Hanne Vibe, Kessing Lars Vedel
Amager Hospital, Department of Psychiatry, Denmark.
Expert Rev Neurother. 2007 Jan;7(1):57-62. doi: 10.1586/14737175.7.1.57.
Depression is a common disorder with painful symptoms and, frequently, social impairment and decreased quality of life. The disorder has a tendency to be long lasting, often with frequent recurrence of symptoms. The risk of relapse and the severity of the symptoms may be reduced by correct antidepressant medication. However, the medication is often insufficient, both in respect to dosage and length of time. The reasons for incorrect medication are many, with lack of adherence to treatment being the most important. Although some patients taking antidepressant medication experience side effects, this may not be the most frequent reason for immature discontinuation of treatment. Other reasons for decreased adherence have been investigated in recent years. The patient's beliefs about the disorder and beliefs about antidepressants, including lack of conviction that the medication is needed and fear of dependence of antidepressant medicine, have a great influence on adherence to treatment.
抑郁症是一种常见疾病,伴有痛苦症状,且常常导致社交障碍和生活质量下降。该疾病往往持续时间较长,症状经常反复出现。正确使用抗抑郁药物可降低复发风险和症状严重程度。然而,药物治疗在剂量和疗程方面往往并不充分。用药不当的原因众多,其中最重要的是治疗依从性差。虽然一些服用抗抑郁药物的患者会出现副作用,但这可能并非治疗提前中断的最常见原因。近年来,人们对依从性降低的其他原因进行了研究。患者对该疾病的看法以及对抗抑郁药物的看法,包括对是否需要用药缺乏信心以及对依赖抗抑郁药物的恐惧,对治疗依从性有很大影响。