Miyamoto T, Miyamoto M, Inoue Y, Usui Y, Suzuki K, Hirata K
Department of Neurology, Dokkyo Medical University School of Medicine, Tochigi 321-0293, Japan.
Neurology. 2006 Dec 26;67(12):2236-8. doi: 10.1212/01.wnl.0000249313.25627.2e.
Idiopathic REM sleep behavior disorder (RBD) may represent prodromal synucleinopathies. We report markedly reduced cardiac (123)I-metaiodobenzylguanidine uptake, consistent with the loss of sympathetic terminals, in idiopathic RBD. We also demonstrate that this reduction is of the same magnitude as that found in patients with Parkinson disease. The results are consistent with the hypothesis that idiopathic RBD in older patients is a forme fruste of Lewy body disease.
特发性快速眼动睡眠行为障碍（RBD）可能是突触核蛋白病的前驱症状。我们报告了特发性RBD患者心脏（123）I-间碘苄胍摄取显著减少，这与交感神经末梢的丧失一致。我们还证明，这种减少的程度与帕金森病患者相同。这些结果与以下假设一致：老年患者的特发性RBD是路易体病的一种顿挫型。
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