斯蒂芬·佩吉特与转移播散的“种子与土壤”理论

Stephen Paget and the 'seed and soil' theory of metastatic dissemination.

作者信息

Ribatti D, Mangialardi G, Vacca A

机构信息

Department of Human Anatomy and Histology, University of Bari Medical School, Piazza G. Cesare 11, Policlinico, I-70124, Bari, Italy.

出版信息

Clin Exp Med. 2006 Dec;6(4):145-9. doi: 10.1007/s10238-006-0117-4.

DOI:10.1007/s10238-006-0117-4

PMID:17191105

Abstract

The outcome of cancer metastasis depends on multiple interactions between selected metastatic cells and homeostatic mechanisms unique to some organ microenvironments. The English surgeon Stephen Paget (1855-1926) is credited with being the first to postulate the important role played by microenvironment in metastasis formation. The concept of his 'seed and soil' theory has been supported and confirmed by numerous publications. This review article summarises the most important literature data about this matter.

摘要

癌症转移的结果取决于特定转移细胞与某些器官微环境特有的稳态机制之间的多种相互作用。英国外科医生斯蒂芬·佩吉特（1855 - 1926）被认为是第一个提出微环境在转移形成中发挥重要作用的人。他的“种子与土壤”理论概念已得到众多出版物的支持和证实。这篇综述文章总结了关于此事的最重要的文献数据。