Wierink C D, Bots-van 't Spijker P C, de Baat C
Uit de differentiatie-opleiding tot tandarts-geriatrie, Universitair Medisch Centrum St Radboud, Nijmegen.
Ned Tijdschr Tandheelkd. 2006 Dec;113(12):502-5.
Parkinson's disease is a slowly progressive and irreversible disorder of the nervous system. Drooling is listed as a secondary symptom of Parkinson's disease. Its cause is insufficiently clear. In the literature 2 possible causes are described: hypersalivation and swallowing abnormalities. These parameters have not been measured in a single study before. This article presents a review of the literature on the subject and describes the design for a future clinical study. The aim of this clinical study is to gain an insight into the cause and the prevalence of drooling in Parkinson's patients. A group of 50 Parkinson's patients will be compared to a group of 50 controls. The objectives of this comparative study comprise the assessment of salivary flow volumes, swallowing capacity, subjective experiences with drooling and an objective observation of drooling, the drooling quotient. Finally, the possibilities for treatment will be described.
帕金森病是一种缓慢进展且不可逆的神经系统疾病。流涎被列为帕金森病的次要症状。其病因尚不完全清楚。文献中描述了2种可能的病因:唾液分泌过多和吞咽异常。此前尚无单一研究对这些参数进行测量。本文对该主题的文献进行了综述,并描述了一项未来临床研究的设计。这项临床研究的目的是深入了解帕金森病患者流涎的原因和患病率。将一组50名帕金森病患者与一组50名对照者进行比较。这项对比研究的目标包括评估唾液流量、吞咽能力、流涎的主观体验以及对流涎的客观观察,即流涎商数。最后,将描述治疗的可能性。