3q27染色体改变对淋巴结B细胞淋巴瘤的预后影响：329例连续患者中与组织学、免疫表型、核型及临床结局的相关性

Prognostic impact of chromosomal alteration of 3q27 on nodal B-cell lymphoma: correlation with histology, immunophenotype, karyotype, and clinical outcome in 329 consecutive patients.

作者信息

Niitsu Nozomi, Okamoto Masataka, Nakamura Naoya, Nakamine Hirokazu, Aoki Sadao, Hirano Masami, Miura Ikuo

机构信息

Division of Hematology, Department of Internal Medicine, Saitama Medical University, Saitama, Japan.

出版信息

Leuk Res. 2007 Sep;31(9):1191-7. doi: 10.1016/j.leukres.2006.11.004. Epub 2007 Jan 2.

DOI:10.1016/j.leukres.2006.11.004

PMID:17197022

Abstract

Rearrangements involving the BCL6 gene are found in 30% of diffuse large B-cell lymphomas (DLBCLs). We evaluated the clinical characteristics and prognoses of patients with B-cell lymphoma carrying 3q27 translocations. Among the 59 patients having 3q27 translocation, 10.9% had follicular lymphoma (FL) and 23.1% had DLBCL. It is of interest that the prognostic significance was not found between FL and DLBCL with 3q27 translocations. Progression-free survival (PFS) rate was significantly higher in the FL patients with 3q27 translocation than in those with 18q21 translocation. PFS rate was significantly higher in the DLBCL patients with 3q27 translocation than in those with 18q21 translocation. These findings suggest that the presence of 3q27 translocation is a significant prognostic factor in DLBCL.

摘要

30%的弥漫性大B细胞淋巴瘤（DLBCL）中存在涉及BCL6基因的重排。我们评估了携带3q27易位的B细胞淋巴瘤患者的临床特征和预后。在59例发生3q27易位的患者中，10.9%患有滤泡性淋巴瘤（FL），23.1%患有DLBCL。有趣的是，在伴有3q27易位的FL和DLBCL之间未发现预后意义的差异。伴有3q27易位的FL患者的无进展生存期（PFS）率显著高于伴有18q21易位的患者。伴有3q27易位的DLBCL患者的PFS率显著高于伴有18q21易位的患者。这些发现表明，3q27易位的存在是DLBCL的一个重要预后因素。