Suppr超能文献

托吡酯对肥胖男性能量平衡的影响:一项为期6个月的双盲随机安慰剂对照研究及为期6个月的开放标签延长期研究。

The effect of topiramate on energy balance in obese men: a 6-month double-blind randomized placebo-controlled study with a 6-month open-label extension.

作者信息

Tremblay Angelo, Chaput Jean-Philippe, Bérubé-Parent Sonia, Prud'homme Denis, Leblanc Claude, Alméras Natalie, Després Jean-Pierre

机构信息

Division of Kinesiology (PEPS), Department of Social and Preventive Medicine, Laval University, G1K 7P4 Québec, Canada.

出版信息

Eur J Clin Pharmacol. 2007 Feb;63(2):123-34. doi: 10.1007/s00228-006-0220-1. Epub 2007 Jan 3.

Abstract

OBJECTIVE

Topiramate (TPM) has been reported to reduce body weight beyond a placebo in the treatment of obese participants, but the effect of this agent on components of energy balance has not yet been established in humans. Thus, the aim of this study was to study the impact of TPM on food preferences, measures of satiety, food intake, resting metabolic rate (RMR), and 24-h energy expenditure.

METHODS

The study design consisted of a 6-month, single-center, randomized, double-blind, parallel group, placebo-controlled trial with a 6-month open-label extension. The study included 68 sedentary men with abdominal obesity (waist circumference > or = 100 cm), of between 25 and 55 years of age, with a dyslipidemic profile and a body mass index (BMI) > or = 27 and < or = 40 kg/m(2).

RESULTS

Treatment with TPM produced significant changes in anthropometric variables and body composition compared with placebo. However, at the end of the 1-year study, the placebo/TPM group showed similar weight loss and reduction in body fatness compared with the TPM/TPM group. For instance, at the end of the 12-month intervention, mean percentage of body weight loss from baseline was about -5% in both groups (-4 kg fat loss). Topiramate treatment reduced energy intake, be it in the context of an ad libitum buffet-type meal or under free living conditions. The 24-h daily energy expenditure (DEE) assessed by whole-body indirect calorimetry adjusted for body weight and age was not altered by TPM treatment.

CONCLUSION

Topiramate treatment produced significantly greater weight loss than placebo and the majority of this loss was explained by a decrease in body fat stores. Most of the weight loss effect produced by TPM therapy was observed within a period of 6 months. Finally, TPM treatment had an impact on energy balance through a reduction in food intake that appears to have created an energy deficit of about 30,000-40,000 kcal compared with treatment with the placebo over 6 months.

摘要

目的

据报道,托吡酯(TPM)在治疗肥胖参与者时,其减重效果超过安慰剂,但该药物对能量平衡各组成部分的影响在人体中尚未明确。因此,本研究的目的是探讨TPM对食物偏好、饱腹感指标、食物摄入量、静息代谢率(RMR)和24小时能量消耗的影响。

方法

研究设计为一项为期6个月的单中心、随机、双盲、平行组、安慰剂对照试验,并延长6个月的开放标签期。研究纳入了68名年龄在25至55岁之间、久坐不动且腹部肥胖(腰围≥100 cm)、血脂异常、体重指数(BMI)≥27且≤40 kg/m²的男性。

结果

与安慰剂相比,TPM治疗使人体测量学变量和身体成分发生了显著变化。然而,在为期1年的研究结束时,安慰剂/TPM组与TPM/TPM组相比,体重减轻和体脂减少情况相似。例如,在12个月干预结束时,两组从基线开始的体重平均减轻百分比约为-5%(脂肪减少4 kg)。托吡酯治疗降低了能量摄入,无论是在随意自助餐式饮食还是自由生活条件下。经体重和年龄调整后通过全身间接测热法评估的24小时每日能量消耗(DEE)并未因TPM治疗而改变。

结论

托吡酯治疗导致的体重减轻显著大于安慰剂,且大部分体重减轻是由于体脂储存减少所致。TPM治疗产生的大部分减重效果在6个月内出现。最后,TPM治疗通过减少食物摄入量对能量平衡产生影响,与安慰剂治疗相比,在6个月内似乎造成了约30,000-40,000千卡的能量 deficit。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验