热带绿叶蔬菜可预防大蒜诱导的大鼠肝毒性。

Biochemistry Department, Federal University of Technology, Akure, Nigeria.

J Med Food. 2006 Winter;9(4):545-51. doi: 10.1089/jmf.2006.9.545.

Garlic (Allium sativum) is popularly consumed because of its role in the treatment and management of several diseases. However, unregulated and chronic intake of garlic can cause damage to cells through the production of free radicals. This study was carried out in order to assess the ability of some tropical green leafy vegetables (Telfairia occidentalis, Solanum macrocapon, Corchorus olitorius, Baselia alba, Cnidoscolus acontifolus, Amarantus cruentus, and Ocimum gratissimum) to prevent garlic-induced hepatotoxicity in rats. Wistar strain albino rats were fed diet containing 4% garlic along with or without 40% green leafy vegetable supplement for 14 days. Thereafter, the feeding trial was terminated, the serum of the blood was prepared, and the liver, spleen, intestine, and organ were isolated for gross pathological investigation. The results of the study revealed that there was a significant increase (P < .05) in serum glutamate-oxaloacetate transaminase (SGOT) and glutamate-pyruvate transaminase (SGPT) of the albino rats fed diet containing 4% garlic supplement when compared with the rats fed the basal diet without garlic and vegetable (40%) supplement. However, there was a significant decrease (P < .05) in the serum total protein and albumin levels in those rats. Conversely, there was a consistent significant decrease (P < .05) in the SGOT and SGPT of the rats fed diet containing garlic (4%) and T. occidentalis (40%) and C. acontifolus (40%) supplement compared with those rats fed diet containing garlic (4%) supplement, while there were no consistent significant decrease in those rats fed diet with garlic (4%) alongside with 40% of other leafy vegetables (S. macrocanum, C. olitorius, B. alba, A. cruentus, and O. gratissimum). An increase in serum level of total protein and albumin was also observed in the rats fed T. occidentalis and C. acontifolus. Thus, T. occidentalis and C. acontifolus proved to be better vegetables in preventing garlic-induced hepatotoxicity compared with the other vegetables used in this study.

大蒜（蒜）因其在多种疾病的治疗和管理中的作用而被广泛食用。然而，无节制和长期摄入大蒜会通过产生自由基对细胞造成损害。本研究旨在评估一些热带绿叶蔬菜（西非油瓜、大果茄、黄麻叶、白背三七、刺头茄、尾穗苋和丁香罗勒）预防大蒜诱导的大鼠肝毒性的能力。将Wistar品系白化大鼠喂食含4%大蒜的饲料，同时添加或不添加40%的绿叶蔬菜补充剂，持续14天。此后，终止喂养试验，制备血液血清，并分离肝脏、脾脏、肠道和器官进行大体病理学研究。研究结果显示，与喂食不含大蒜和蔬菜（40%）补充剂的基础饲料的大鼠相比，喂食含4%大蒜补充剂饲料的白化大鼠血清谷氨酸草酰乙酸转氨酶（SGOT）和谷氨酸丙酮酸转氨酶（SGPT）显著升高（P < 0.05）。然而，这些大鼠的血清总蛋白和白蛋白水平显著降低（P < 0.05）。相反，与喂食含4%大蒜补充剂饲料的大鼠相比，喂食含大蒜（4%）和西非油瓜（40%）以及刺头茄（40%）补充剂饲料的大鼠的SGOT和SGPT持续显著降低（P < 0.05），而喂食含大蒜（4%）和40%其他绿叶蔬菜（大果茄、黄麻叶、白背三七、尾穗苋和丁香罗勒）饲料的大鼠则没有持续显著降低。在喂食西非油瓜和刺头茄的大鼠中还观察到血清总蛋白和白蛋白水平升高。因此，与本研究中使用的其他蔬菜相比，西非油瓜和刺头茄在预防大蒜诱导的肝毒性方面被证明是更好的蔬菜。