莱伯遗传性视神经病变可能由接触轮胎火灾引发。

Leber hereditary optic neuropathy possibly triggered by exposure to tire fire.

作者信息

Sanchez Ruben N, Smith Allison J, Carelli Valerio, Sadun Alfredo A, Keltner John L

机构信息

Department of Ophthalmology, Doheny Eye Institute, University of Southern California, Keck School of Medicine, Los Angeles, California, USA.

出版信息

J Neuroophthalmol. 2006 Dec;26(4):268-72. doi: 10.1097/01.wno.0000249320.27110.ab.

DOI:10.1097/01.wno.0000249320.27110.ab

PMID:17204920

Abstract

We report three members of one family, a mother and two daughters aged 4 and 7 years, who developed visual loss from Leber hereditary optic neuropathy within a 19-month period. All three had been exposed to smoke from two large rubber tire fires within the previous 24 months, suggesting the possibility of an epigenetic triggering factor.

摘要

我们报告了一个家庭的三名成员，一位母亲和两名分别为4岁和7岁的女儿，她们在19个月内患上了由Leber遗传性视神经病变导致的视力丧失。这三人在之前的24个月内都接触过两场大型橡胶轮胎火灾产生的烟雾，提示存在表观遗传触发因素的可能性。