使用表面增强激光解吸/电离飞行时间质谱法进行血浆蛋白谱分析以检测子宫内膜异位症。
Detection of endometriosis with the use of plasma protein profiling by surface-enhanced laser desorption/ionization time-of-flight mass spectrometry.
作者信息
Liu Haiyuan, Lang Jinghe, Zhou Qunfang, Shan Dan, Li Qizhai
出版信息
Fertil Steril. 2007 Apr;87(4):988-90. doi: 10.1016/j.fertnstert.2006.08.095. Epub 2007 Jan 4.
Abstract
In this prospective case-control study, we determined the role of surface-enhanced laser desorption and ionization time-of-flight mass spectrometry in the detection of histologically proven endometriosis. In the plasma of the group with endometriosis, there were 20 different protein peaks, and the classifier showed a sensitivity of 87.5% and a specificity of 80% in the diagnosis of endometriosis.
摘要
在这项前瞻性病例对照研究中，我们确定了表面增强激光解吸电离飞行时间质谱在经组织学证实的子宫内膜异位症检测中的作用。在子宫内膜异位症组的血浆中，有20个不同的蛋白质峰，并且该分类器在子宫内膜异位症诊断中的灵敏度为87.5%，特异性为80%。
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