Hamann A, Jablonski-Westrich D, Jonas P, Thiele H G
Department of Immunology, I. Medizinische Klinik, Universitätskrankenhaus, Eppendorf, Hamburg, FRG.
Eur J Immunol. 1991 Dec;21(12):2925-9. doi: 10.1002/eji.1830211205.
Specific recognition molecules ("homing receptors") on lymphocytes are thought to direct selective entry of cells into different organs. The lectin-related cell adhesion molecule LECAM-1 has previously been supposed to mediate lymphocyte entry into peripheral lymph nodes and, partially, mesenteric nodes but not into Peyer's patches. Here we present evidence that in vivo the molecule is also implicated in homing of mouse lymphocytes to Peyer's patches and may have a more general role as homing receptor for high endothelial venules-bearing lymphoid tissue, but not for most non-lymphoid tissue.
淋巴细胞上的特异性识别分子（“归巢受体”）被认为可引导细胞选择性进入不同器官。此前认为凝集素相关细胞黏附分子LECAM-1介导淋巴细胞进入外周淋巴结，部分介导进入肠系膜淋巴结，但不介导进入派氏结。在此我们提供证据表明，在体内该分子也与小鼠淋巴细胞归巢至派氏结有关，并且可能作为带有高内皮微静脉的淋巴组织的归巢受体发挥更广泛的作用，但对大多数非淋巴组织不起作用。
