Aleksandrowicz Jerzy W, Urbanik Andrzej, Binder Marek
Katedra Psychoterapii CM UJ, Kraków.
Psychiatr Pol. 2006 Sep-Oct;40(5):969-83.
The aim of the study was imaging of the central nervous system activity with the fMRI method during hypnosis as well as confirmation of the observations linking subjective effects of suggested analgesia with the functional changes on the neurophysiological level.
At first volunteers (7 female, 7 male) were examined with fMRI in the resting state and then four times during application of painful stimuli such as pricking of the right hand. Four experimental conditions were associated with this stimulation: only nociceptive stimulation, after analgesic suggestion, after hypnotic induction and after consecutive analgesic suggestion in hypnosis. In the fifth condition, concentration of attention was an experimental condition, while the control condition was distraction of attention (e.g. free associations). The contrast differences between measurements in the consecutive phases of the experiment were analysed.
Decreases of activity of regions known for contributing to pain reception were found, probably as an effect of analgesic suggestion. This effect was seen especially in the area of L-thalamus. Suggestion (more precisely--the reception of its content) was related mainly to the R-ACG area activity growth. Hypnotic induction was correlated with increasing activity of the L-orbitofrontal gyrus. Concentration of attention was linked with activity increase within inferior parietal lobule, occipital middle/superior gyri; in the left hemisphere in the orbital frontal gyri and insula/frontal operculum.
Both hypnosis and reception of analgesic suggestion are linked with increasing activity in particular brain areas, whereas the effect of analgesic suggestion demonstrates itself in the fMRI mainly by diminishing the reaction on painful stimuli.
本研究的目的是在催眠过程中使用功能磁共振成像（fMRI）方法对中枢神经系统活动进行成像，并证实将暗示性镇痛的主观效果与神经生理水平的功能变化联系起来的观察结果。
首先，对志愿者（7名女性，7名男性）在静息状态下进行fMRI检查，然后在施加疼痛刺激（如右手刺痛）期间进行四次检查。与这种刺激相关的有四种实验条件：仅伤害性刺激、镇痛暗示后、催眠诱导后以及催眠中连续镇痛暗示后。在第五种条件下，注意力集中是实验条件，而对照条件是注意力分散（如自由联想）。分析了实验连续阶段测量之间的对比差异。
发现已知对疼痛感受有贡献的区域的活动减少，这可能是镇痛暗示的作用。这种效应尤其在左侧丘脑区域可见。暗示（更确切地说——对其内容的接受）主要与右侧前扣带回区域的活动增加有关。催眠诱导与左侧眶额回的活动增加相关。注意力集中与顶下小叶、枕中/上回内的活动增加有关；在左侧半球，眶额回和岛叶/额盖也有活动增加。
催眠和镇痛暗示的接受都与特定脑区活动的增加有关，而镇痛暗示的效果在fMRI中主要表现为对疼痛刺激反应的减弱。
