Lackner Andrew A, Veazey Ronald S
Tulane National Primate Research Center, Covington, Louisiana 70433, USA.
Annu Rev Med. 2007;58:461-76. doi: 10.1146/annurev.med.58.082405.094316.
The pathogenesis of AIDS has proven to be quite complex and dynamic, with most of the critical events (e.g., transmission, CD4(+) T cell destruction) occurring in tissues that are not easily accessible for analysis. In addition, although the disease can progress over years, many critical events happen within the first few weeks of infection, when most patients are unaware that they are infected. The nonhuman primate model of AIDS has been used extensively to fill these gaps in our understanding of AIDS pathogenesis.
事实证明，艾滋病的发病机制非常复杂且具有动态性，大多数关键事件（如传播、CD4(+) T细胞破坏）发生在难以进行分析的组织中。此外，尽管该疾病可能会持续数年发展，但许多关键事件发生在感染后的头几周内，而此时大多数患者并未意识到自己已被感染。艾滋病的非人灵长类动物模型已被广泛用于填补我们在艾滋病发病机制理解上的这些空白。
