Sotiriadis Alexandros, Vartholomatos George, Pavlou Matthaios, Kolaitis Nicolaos, Dova Leucothea, Stefos Theodor, Paraskevaidis Evangelos, Kalantaridou Sophia N
Department of Obstetrics and Gynecology, University Hospital of Ioannina, Ioannina, Greece.
Am J Reprod Immunol. 2007 Feb;57(2):133-41. doi: 10.1111/j.1600-0897.2006.00454.x.
To compare the prevalence of five common thrombophilic polymorphisms and their combination in women with recurrent miscarriage and a control group.
Genomic analysis using polymerase chain reaction (PCR) was carried out in patients with two or more miscarriages and controls for Factor V Leiden, Factor V A1299H (HR2), Factor II G20210A, MTHFR C677T and MTHFR A1298C. Secondary analyses were made for number of miscarriages and gestational age at miscarriage.
None the mutations was associated with significantly increased risk for recurrent miscarriage. The prevalence of combined thrombophilias (4/88 versus 2/88) did not increase the risk for miscarriage (OR 2.04, 95% CI 0.36-11.47). Although virtually all patients with thrombophilia had miscarriages<or=10 weeks, statistical significance was not reached due to the small size of the >10 weeks' subgroup. There was no difference in the distribution of Factor V Leiden (P=1.000), FII G20210A (P=0.652), and MTHFR C677T (P=0.869) between patients with two and three or more miscarriages, whereas MTHFR A1298C was more common among patients with two miscarriages (P=0.017).
Combinations of the five thrombophilic mutations studied are an uncommon event with heterogeneous pattern and they do not significantly increase the risk for miscarriage.
比较复发性流产女性与对照组中五种常见血栓形成倾向多态性及其组合的患病率。
对有两次或更多次流产的患者及对照组进行聚合酶链反应（PCR）基因分析，检测凝血因子V Leiden、凝血因子V A1299H（HR2）、凝血因子II G20210A、亚甲基四氢叶酸还原酶（MTHFR）C677T和MTHFR A1298C。对流产次数和流产时的孕周进行了二次分析。
没有一种突变与复发性流产风险的显著增加相关。合并血栓形成倾向的患病率（4/88对2/88）并未增加流产风险（比值比2.04，95%可信区间0.36 - 11.47）。虽然几乎所有血栓形成倾向患者的流产都发生在≤10周，但由于>10周亚组样本量小，未达到统计学显著性。两次流产患者与三次或更多次流产患者之间，凝血因子V Leiden（P = 1.000）、凝血因子II G20210A（P = 0.652）和MTHFR C677T（P = 0.869）的分布没有差异，而MTHFR A1298C在两次流产患者中更常见（P = 0.017）。
所研究的五种血栓形成倾向突变的组合并不常见，模式各异，且不会显著增加流产风险。
