[慢性非球形红细胞溶血性贫血患者红细胞中葡萄糖-6-磷酸脱氢酶的新变体（G-6-PD“卡卢加”）]

[New variant of glucose-6-phosphate dehydrogenase (G-6-PD "Kaluga") from erythrocytes of a patient with chronic nonspherocytic hemolytic anemia].

作者信息

Shatskaia T L, Krasnopol'skaia K D, Idel'son L I

出版信息

Vopr Med Khim. 1976 Nov-Dec;22(6):764-8.

PMID:17221

Abstract

Properties of a new form of glucose-6-phosphate dehydrogenase (G6PD) from erythrocytes, called "Kaluga", are described. The enzyme was isolated from erythrocytes of a patient with chronic non-spherocytic hemolytic anemia; in the blood cells 20% of the G6PD activity was maintained as compared with normal state. The partially purified enzyme was shown to be unstable in electrophoresis, it possessed a biphase type of pH-optima; Km value for NADP was decreased for glucose-6-phosphate Km value was normal. The thermostability of G6PD was normal at 46 within 1 hr.

摘要

描述了一种来自红细胞的新型葡萄糖-6-磷酸脱氢酶（G6PD）“卡卢加”的特性。该酶从一名慢性非球形细胞溶血性贫血患者的红细胞中分离得到；与正常状态相比，血细胞中G6PD活性维持在20%。部分纯化的酶在电泳中显示不稳定，具有双相pH最适类型；NADP的Km值降低，而葡萄糖-6-磷酸的Km值正常。G6PD在46℃下1小时内的热稳定性正常。

相似文献

1

[New variant of glucose-6-phosphate dehydrogenase (G-6-PD "Kaluga") from erythrocytes of a patient with chronic nonspherocytic hemolytic anemia].[慢性非球形红细胞溶血性贫血患者红细胞中葡萄糖-6-磷酸脱氢酶的新变体（G-6-PD“卡卢加”）]

Vopr Med Khim. 1976 Nov-Dec;22(6):764-8.

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Characteristics of a new abnormal variant of G-6-PD in human red cells.人类红细胞中葡萄糖-6-磷酸脱氢酶（G-6-PD）一种新的异常变体的特征

Acta Biol Med Ger. 1977;36(5-6):753-8.

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[Electrophoretic and kinetic properties of the erythrocyte glucose-6-phosphate dehydrogenase of patients with hemolytic anemia related to a deficit in the activity of that enzyme].[与葡萄糖-6-磷酸脱氢酶活性缺乏相关的溶血性贫血患者红细胞葡萄糖-6-磷酸脱氢酶的电泳及动力学特性]

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G6PD Baudelocque: a new unstable variant characterized in cultured fibroblasts.葡萄糖-6-磷酸脱氢酶波德洛克变异型：一种在培养的成纤维细胞中鉴定出的新型不稳定变异体。

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G6PD Varadero. A new variant of glucose-6-phosphate dehydrogenase associated with congenital nonspherocytic hemolytic anemia.G6PD 巴亚莫型。一种与先天性非球形红细胞溶血性贫血相关的葡萄糖 -6- 磷酸脱氢酶新变体。

Vox Sang. 1982;43(2):102-4. doi: 10.1111/j.1423-0410.1982.tb00533.x.

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Hereditary hemolytic anemia due to glucose-6-phosphate dehydrogenase Torrance: a new variant.葡萄糖-6-磷酸脱氢酶托伦斯所致的遗传性溶血性贫血：一种新变体。

J Lab Clin Med. 1969 Apr;73(4):657-67.

10

Three new electrophoretically normal glucose-6-phosphate dehydrogenase variants associated with congenital nonspherocytic hemolytic anemia found in Japan: G6PD Ogikubo, Yokohama, and Akita.在日本发现三种与先天性非球形红细胞溶血性贫血相关的新的电泳正常的葡萄糖-6-磷酸脱氢酶变异体：G6PD 荻洼型、横滨型和秋田型。

Hum Genet. 1978 Nov 24;45(1):11-7. doi: 10.1007/BF00277568.

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