Nabika Shinya, Kiya Katsuzo, Satoh Hideki, Mizoue Tatsuya, Oshita Jumpei, Kondo Hiroshi
Department of Neurosurgery, Hiroshima Prefectural Hospital, Japan.
No Shinkei Geka. 2007 Jan;35(1):27-32.
The authors report a retrospective review o f 70 patients followed up for the presence of incidental, asymptomatic meningiomas. A survey was conducted of primary intracranial tumors diagnosed in Hiroshima Prefectural Hospital between 1995 and 2004. The neuroradiological imaging and clinical studies for asymptomatic meningiomas were performed during the 57.5-month mean follow-up period. Of the asymptomatic 70 meningiomas, 34 (mean age 58.3yrs) were surgically removed just after diagnosis, whereas 36 (mean age 72.1yrs) were treated conservatively. There was no permanent morbidity. Five patients (13%) had the transient operation-related neurological morbidity, which was caused by venous congestion near eloquent area, or operative manipulation at the craniotomy. The transient morbidity in patients over 70 years was 20%, although it was 12% in patients under 70 years. Eight patients (21%) were complained of chronic pain at the wound and 5 of them had medication. In 11(30.6%) of these 36 cases treated conservatively, the tumor size increased by mean 0.24 cm/year. Three of them had operation. The tumor growth rate was 0.33 cm/year in the operative group, whereas it was 0.09 cm/year in the conservative group. Histological grading of 3 cases revealed WHO grade I meningiomas. The absence of calcification and high intensity on T2 weighted-imaging were significantly associated with the higher growth rate (p<0.05). We should decide the strategy for treatment, paying attention to the radiological features, the tumor growth rate, age and operative difficulty. In addition that, we should keep in mind that over 20% patients were suffered from postoperative painful wound.
作者报告了一项对70例因偶然发现的无症状脑膜瘤而接受随访的患者的回顾性研究。对1995年至2004年间广岛县立医院诊断的原发性颅内肿瘤进行了一项调查。在平均57.5个月的随访期内,对无症状脑膜瘤进行了神经放射学成像和临床研究。在这70例无症状脑膜瘤中,34例(平均年龄58.3岁)在诊断后立即接受了手术切除,而36例(平均年龄72.1岁)接受了保守治疗。没有永久性并发症。5例患者(13%)出现了与手术相关的短暂性神经并发症,这是由功能区附近的静脉淤血或开颅手术时的操作引起的。70岁以上患者的短暂性并发症发生率为20%,而70岁以下患者为12%。8例患者(21%)抱怨伤口慢性疼痛,其中5例需要药物治疗。在这36例接受保守治疗的患者中,11例(30.6%)肿瘤大小平均每年增加0.24厘米。其中3例接受了手术。手术组的肿瘤生长速度为每年0.33厘米,而保守组为每年0.09厘米。3例患者的组织学分级显示为世界卫生组织I级脑膜瘤。T2加权成像上无钙化和高强度与较高的生长速度显著相关(p<0.05)。我们应根据放射学特征、肿瘤生长速度、年龄和手术难度来决定治疗策略。此外,我们应记住,超过20%的患者术后伤口疼痛。