Finn Robert D, Stalker James W, Jackson David K, Kulesha Eugene, Clements Jody, Pettett Roger
Wellcome Trust Sanger Institute, Wellcome Trust Geome Campus, Hinxton, Cambridge, UK.
Bioinformatics. 2007 Jun 15;23(12):1568-70. doi: 10.1093/bioinformatics/btl650. Epub 2007 Jan 18.
The increasing size and complexity of biological databases has led to a growing trend to federate rather than duplicate them. In order to share data between federated databases, protocols for the exchange mechanism must be developed. One such data exchange protocol that is widely used is the Distributed Annotation System (DAS). For example, DAS has enabled small experimental groups to integrate their data into the Ensembl genome browser. We have developed ProServer, a simple, lightweight, Perl-based DAS server that does not depend on a separate HTTP server. The ProServer package is easily extensible, allowing data to be served from almost any underlying data model. Recent additions to the DAS protocol have enabled both structure and alignment (sequence and structural) data to be exchanged. ProServer allows both of these data types to be served.
ProServer can be downloaded from http://www.sanger.ac.uk/proserver/ or CPAN http://search.cpan.org/~rpettett/. Details on the system requirements and installation of ProServer can be found at http://www.sanger.ac.uk/proserver/.
生物数据库规模的不断扩大和复杂性的日益增加，导致联合而非复制这些数据库的趋势日益明显。为了在联合数据库之间共享数据，必须开发用于交换机制的协议。分布式注释系统（DAS）就是一种广泛使用的数据交换协议。例如，DAS使小型实验组能够将其数据集成到Ensembl基因组浏览器中。我们开发了ProServer，这是一个简单、轻量级的基于Perl的DAS服务器，不依赖于单独的HTTP服务器。ProServer包易于扩展，允许从几乎任何底层数据模型提供数据。DAS协议的最新扩展使得结构数据和比对（序列和结构）数据都能够进行交换。ProServer能够提供这两种数据类型。
ProServer可从http://www.sanger.ac.uk/proserver/或CPAN http://search.cpan.org/~rpettett/下载。有关ProServer系统要求和安装的详细信息可在http://www.sanger.ac.uk/proserver/上找到。
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