神经退行性变：千疮百孔。
Neurodegeneration: nicked to death.
作者信息
Wilson David M, Mattson Mark P
机构信息
Laboratory of Molecular Gerontology, National Institute on Aging Intramural Research Program, Baltimore, Maryland, USA.
出版信息
Curr Biol. 2007 Jan 23;17(2):R55-8. doi: 10.1016/j.cub.2006.12.012.
PMID:17240329
Abstract
Ataxia oculomotor apraxia-1 is a neurological disorder that arises from mutations in the gene encoding the protein aprataxin. A recent study demonstrates that aprataxin is critical for the processing of obstructive DNA termini, suggesting a broader role for DNA single-strand break repair in neurodegenerative disease.
摘要
动眼性共济失调1型是一种神经障碍疾病，由编码aprataxin蛋白的基因突变引起。最近一项研究表明，aprataxin对于阻塞性DNA末端的处理至关重要，这表明DNA单链断裂修复在神经退行性疾病中可能发挥更广泛的作用。
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