Ares S, Kalosakas G
Max Planck Institute for the Physics of Complex Systems, Nöthnitzer Strasse 38, D-01187 Dresden, Germany.
Nano Lett. 2007 Feb;7(2):307-11. doi: 10.1021/nl062304a. Epub 2007 Jan 23.
The distribution of bubble lengths in double-stranded DNA is presented for segments of varying guanine-cytosine (GC) content, obtained with Monte Carlo simulations using the Peyrard-Bishop-Dauxois model at 310 K. An analytical description of the obtained distribution in the whole regime investigated, i.e., up to bubble widths of the order of tens of nanometers, is available. We find that the decay lengths and characteristic exponents of this distribution show two distinct regimes as a function of GC content. The observed distribution is attributed to the anharmonic interactions within base pairs. The results are discussed in the framework of the Poland-Scheraga and the Peyrard-Bishop (with linear instead of nonlinear stacking interaction) models.
给出了在310K下使用佩拉尔-毕晓普-多索瓦模型通过蒙特卡罗模拟获得的不同鸟嘌呤-胞嘧啶（GC）含量的双链DNA片段中气泡长度的分布。对于所研究的整个区域，即直至几十纳米量级的气泡宽度，都有对所得分布的解析描述。我们发现，该分布的衰减长度和特征指数作为GC含量的函数呈现出两种不同的状态。观察到的分布归因于碱基对内的非谐相互作用。在波兰-谢拉加模型和佩拉尔-毕晓普模型（具有线性而非非线性堆积相互作用）的框架内对结果进行了讨论。
