Kukreja R C
Department of Internal Medicine, Division of Cardiology, Virginia Commonwealth University, Richmond, VA 23298, USA.
Br J Pharmacol. 2007 Mar;150(5):538-40. doi: 10.1038/sj.bjp.0707132. Epub 2007 Jan 22.
During the past 18 years, sildenafil has evolved from a potential anti-angina drug to an on-demand treatment for erectile dysfunction and more recently to a new orally active treatment for pulmonary hypertension. Recent studies suggest that the drug has powerful cardioprotective effect against ischemia/reperfusion injury, doxorubicin-induced cardiomyopathy and anti-hypertensive effect induced by chronic inhibition of nitric oxide synthase in animals. Based on several recent basic and clinical studies, it is clear that sildenafil and other clinically approved type-5 phosphodiesterase-5 inhibitors including vardenafil and tadalafil will eventually be developed for several cardiovascular indications including essential hypertension, endothelial dysfunction, ischemia/reperfusion injury, myocardial infarction, ventricular remodeling and heart failure.
在过去的18年里,西地那非已从一种潜在的抗心绞痛药物发展成为按需治疗勃起功能障碍的药物,最近又成为一种新型的口服活性肺动脉高压治疗药物。最近的研究表明,该药物对动物的缺血/再灌注损伤、阿霉素诱导的心肌病具有强大的心脏保护作用,并且对慢性一氧化氮合酶抑制诱导的高血压具有降压作用。基于最近的一些基础和临床研究,很明显西地那非和其他临床批准的5型磷酸二酯酶-5抑制剂(包括伐地那非和他达拉非)最终将被开发用于多种心血管适应症,包括原发性高血压、内皮功能障碍、缺血/再灌注损伤、心肌梗死、心室重塑和心力衰竭。