Müller J G, Stahl-Hennig C, Rethwilm A, Kneitz C, Kerkau T, Schmauser B, Schindler C, Krenn V, terMeulen V, Müller-Hermelink H K
Pathologisches Institut Würzburg.
Verh Dtsch Ges Pathol. 1991;75:102-7.
Rhesus monkeys (M. mulatta) were i.v. infected with SIV mac251. Three phases of lymph node changes were observed. 1: physiological follicular hyperplasia (3 and 6 weeks p.i.). 2: Alterations of germinal centers: loss of follicular mantle zone, fragmentation or sclerosis (12 and 24 weeks p.i.). 3: Partial depletion of T-lymphocytes, accumulation of plasma cells, increased numbers of syncytial giant cells, hemophgocytosis in the sinuses (about 1 year p.i.). The thymus of the juvenile animals showed first changes 12 and 24 weeks after infection with focal loss of immature (and Ki-67 positive) cortical thymocytes, leading to severe accidental involution of the thymuses one year after infection and reduced numbers of Hassalls corpuscles. These investigations show the value of this animal model for the study of morphology and pathogenesis of AIDS.
恒河猴（猕猴）经静脉注射感染了猴免疫缺陷病毒mac251。观察到淋巴结变化的三个阶段。1：生理性滤泡增生（感染后3周和6周）。2：生发中心改变：滤泡套区缺失、碎片化或硬化（感染后12周和24周）。3：T淋巴细胞部分耗竭、浆细胞积聚、合胞体巨细胞数量增加、窦内出现噬血细胞现象（感染后约1年）。幼年动物的胸腺在感染后12周和24周首次出现变化，表现为未成熟（且Ki-67阳性）皮质胸腺细胞局灶性缺失，导致感染1年后胸腺严重意外萎缩，哈氏小体数量减少。这些研究表明了该动物模型在艾滋病形态学和发病机制研究中的价值。
