通过对映选择性有机催化多米诺氧杂-迈克尔-羟醛反应一锅法合成手性色烯
One-pot approach to chiral chromenes via enantioselective organocatalytic domino oxa-Michael-aldol reaction.
作者信息
Li Hao, Wang Jian, E-Nunu Timiyin, Zu Liansuo, Jiang Wei, Wei Shaohua, Wang Wei
机构信息
Department of Chemistry, University of New Mexico, Albuquerque, NM 87131, USA.
出版信息
Chem Commun (Camb). 2007 Feb 7(5):507-9. doi: 10.1039/b611502k. Epub 2006 Nov 1.
DOI:10.1039/b611502k
PMID:17252110
Abstract
A highly enantioselective (S)-diphenylpyrrolinol triethylsilyl ether promoted tandem oxa-Michael-aldol reaction of alpha,beta-unsaturated aldehydes with salicylaldehydes has been developed; the method affords one-pot access to chiral and synthetically useful chromenes in high yields and high enantioselectivities from readily available compounds.
摘要
已开发出一种高度对映选择性的（S）-二苯基吡咯啉醇三乙基甲硅烷基醚促进的α，β-不饱和醛与水杨醛的串联氧杂-Michael-aldol反应；该方法能从容易获得的化合物中一锅法高产率、高对映选择性地得到手性且具有合成用途的色烯。
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