[病毒与乳腺癌发生]

[Viruses and mammary carcinogenesis].

作者信息

Vokaer A

出版信息

J Gynecol Obstet Biol Reprod (Paris). 1975;4 SUPPL 2:199-205.

Abstract

Bittner virus has been extensively studied by recent electron microscopy and molecular biology techniques. The structure, the biochemical, physical and antigenic properties of the RNA tumor viruses - i.e. the mouse mammary tumor virus (MMTV) - are well known. Recent observations in human tissues of particles similar to animal viruses that are known to be oncogenic have raised the hypothesis of the role of viruses in human cancer. In mice, breast cancer can be caused by a virus - the Bittner virus or MMTV - that is usually transmitted from mother to offspring in the milk. The discovery of such virus particles in human milks and breast cancer tissues could provide data about a viral aetiology of human breast cancer.

摘要

最近，通过电子显微镜和分子生物学技术对比特纳病毒进行了广泛研究。RNA肿瘤病毒，即小鼠乳腺肿瘤病毒（MMTV）的结构、生化、物理和抗原特性已为人熟知。最近在人体组织中观察到与已知致癌的动物病毒相似的颗粒，这引发了关于病毒在人类癌症中作用的假说。在小鼠中，乳腺癌可由一种病毒——比特纳病毒或MMTV——引起，这种病毒通常通过乳汁从母亲传播给后代。在人乳和乳腺癌组织中发现此类病毒颗粒可为人类乳腺癌的病毒病因学提供数据。