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一项随机前瞻性研究,比较在成人获得性平足畸形手术矫正的外侧柱延长组件中使用三皮质髂嵴自体骨移植与同种异体骨移植的效果。

Randomized prospective study comparing tri-cortical iliac crest autograft to allograft in the lateral column lengthening component for operative correction of adult acquired flatfoot deformity.

作者信息

Dolan Christopher M, Henning Jeffrey A, Anderson John G, Bohay Donald R, Kornmesser Marc J, Endres Terrence J

机构信息

Grand Rapids Medical Education and Research Center, Michigan State University, School of Medicine, 2319 Burchard Street SE, Grand Rapids, MI 49506, USA.

出版信息

Foot Ankle Int. 2007 Jan;28(1):8-12. doi: 10.3113/FAI.2007.0002.

Abstract

BACKGROUND

Operative treatment of stage II posterior tibial tendon insufficiency (PTTI) is controversial. Many soft-tissue and bony procedures and various combinations of the two have been reported for treatment of stage II PTTI. Orthopaedists recognize the lateral column lengthening component of the procedure as a successful reconstructive technique. The use of cortical allograft for lateral column lengthening in the correction of pes planus in the pediatric patient population has been routine. In the adult population, however, tricortical iliac crest autograft has been the bone graft of choice. Harvest of this autograft can precipitate significant morbidity and cost. Therefore, we undertook this randomized controlled trial to compare graft incorporation and healing of allograft and autograft in the lateral column lengthening component of adult flatfoot reconstruction.

METHODS

Lateral column lengthening was done as a component of operative correction for stage II PTTI in adult patients (older than 18 years) by two surgeons using similar procedures. The patients were randomized to either the allograft or autograft procedures. The primary endpoint was graft incorporation and healing as assessed by radiographs.

RESULTS

The study included 33 randomized feet in 31 patients. We followed 18 feet in the allograft group and 15 in the autograft group to the point of union. There were 21 women and 10 men. There were no delayed unions, nonunions, or hardware failures. All patients in both groups achieved bony union by the 12-week followup evaluation. Two superficial foot infections were successfully treated with oral antibiotics. Two patients in the autograft group continued to have hip donor site pain at 3 months.

CONCLUSIONS

This study suggests that union rates of allograft and autograft (iliac crest bone graft) are equal. The use of allograft in the lateral column lengthening component of operative correction of adult stage II PTTI appears to be a viable alternative to the use of iliac crest autograft and eliminates the morbidity and increased cost associated with autograft harvest.

摘要

背景

II期胫后肌腱功能不全(PTTI)的手术治疗存在争议。已有许多软组织和骨手术以及两者的各种组合被报道用于治疗II期PTTI。骨科医生认为该手术中的外侧柱延长部分是一种成功的重建技术。在儿科患者群体中,使用皮质同种异体骨进行外侧柱延长以矫正扁平足已成为常规操作。然而,在成人中,三皮质髂嵴自体骨一直是首选的骨移植材料。获取这种自体骨会引发显著的发病率和成本。因此,我们进行了这项随机对照试验,以比较同种异体骨和自体骨在成人扁平足重建外侧柱延长部分的骨融合和愈合情况。

方法

由两位外科医生采用相似的手术方法,对成年患者(年龄大于18岁)的II期PTTI进行手术矫正,其中外侧柱延长作为手术的一部分。患者被随机分为同种异体骨组或自体骨组。主要终点是通过X线片评估的骨融合和愈合情况。

结果

该研究纳入了31例患者的33只随机分组的足。我们对同种异体骨组的18只足和自体骨组的15只足进行随访直至愈合。患者中有21名女性和10名男性。没有出现延迟愈合、不愈合或内固定失败的情况。两组所有患者在12周的随访评估时均实现了骨愈合。两例表浅足部感染经口服抗生素成功治疗。自体骨组有两名患者在3个月时供体部位的髋部仍持续疼痛。

结论

本研究表明同种异体骨和自体骨(髂嵴骨移植)的愈合率相同。在成人II期PTTI手术矫正的外侧柱延长部分使用同种异体骨似乎是髂嵴自体骨移植的可行替代方法,并且消除了与自体骨获取相关的发病率和成本增加问题。

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