Clemens B, Piros P, Bessenyei M, Hollódy K
Kenézy Gyula Memorial Hospital, Department of Neurology, Epilepsy Center, Debrecen, Hungary.
Clin Neurophysiol. 2007 Apr;118(4):910-7. doi: 10.1016/j.clinph.2006.11.016. Epub 2007 Jan 26.
To investigate the quantitative EEG effects of lamotrigine (LTG) monotherapy.
LTG was predicted to decrease thalamo-cortical neuronal synchronization in idiopathic generalized epilepsy (IGE).
Waking EEG background activity of 19 IGE patients was investigated before treatment and in the course of LTG monotherapy. Raw absolute power (RAP), raw percent power (RRP), and raw mean frequency (RMF) were computed for 19 electrodes and four frequency bands (delta=1.5-3.5Hz, theta=3.5-7.5Hz, alpha=7.5-12.5Hz, and beta=12.5-25.0Hz). Inter- and intrahemispheric coherence was computed for eight electrode pairs and the four frequency bands. In addition, scalp-averages were calculated for each variable. Group differences were computed by means of nonparametric statistics including correction for multiple comparisons.
Main results were decreased delta and theta RAP (p<0.05 for scalp-averages). LTG compressed the delta, theta, and alpha RAP datasets, reducing the upper limit of the scatter in particular. Spearman r-values indicated marked correlation between the starting values (RAPuntreated) and the LTG-related decrease (RAPtreated-RAPuntreated) in three bands: delta (r=-0.72; p=0.0005), theta (r=-0.59; p=0.007), and alpha (r=-0.61; p=0.006). Thus, the greater the baseline neuronal synchronization, the marked the dampening effect of LTG on it. The remaining findings were decreased theta RRP, theta RMF, and increased alpha RMF (p<0.05 for scalp-averages). The electrode-related changes were small but topographically consistent across the 19 electrode sites. LTG did not affect coherence.
The results contribute to the understanding of the effect of LTG at the network level.
研究拉莫三嗪（LTG）单药治疗对脑电图定量分析的影响。
预计LTG可降低特发性全身性癫痫（IGE）中丘脑 - 皮质神经元同步性。
对19例IGE患者在治疗前及LTG单药治疗过程中进行清醒脑电图背景活动研究。计算19个电极和四个频段（δ = 1.5 - 3.5Hz，θ = 3.5 - 7.5Hz，α = 7.5 - 12.5Hz，β = 12.5 - 25.0Hz）的原始绝对功率（RAP）、原始功率百分比（RRP）和原始平均频率（RMF）。计算八个电极对和四个频段的半球间及半球内相干性。此外，计算每个变量的头皮平均值。通过非参数统计方法计算组间差异，包括多重比较校正。
主要结果为δ和θ频段的RAP降低（头皮平均值p < 0.05）。LTG压缩了δ、θ和α频段的RAP数据集，尤其降低了离散度的上限。Spearman相关系数r值表明，在三个频段中，起始值（未治疗时的RAP）与LTG相关的降低值（治疗后的RAP - 未治疗时的RAP）之间存在显著相关性：δ频段（r = -0.72；p = 0.0005）、θ频段（r = -0.59；p = 0.007）和α频段（r = -0.61；p = 0.006）。因此，基线神经元同步性越高，LTG对其抑制作用越显著。其余结果为θ频段的RRP降低、θ频段的RMF降低以及α频段的RMF升高（头皮平均值p < 0.05）。电极相关变化较小，但在19个电极位点上具有地形一致性。LTG不影响相干性。
这些结果有助于在网络层面理解LTG的作用。
Zotero 插件