通过无过渡金属的Meerwein芳基化反应实现α-芳基甲基酮的实用合成。
A practical synthesis of alpha-aryl methyl ketones via a transition-metal-free Meerwein arylation.
作者信息
Molinaro Carmela, Mowat Jeffrey, Gosselin Francis, O'Shea Paul D, Marcoux Jean-François, Angelaud Rémy, Davies Ian W
机构信息
Department of Process Research, Merck Frosst Centre for Therapeutic Research, 16711 Autoroute Transcanadienne, Kirkland, Québec, Canada H9H 3L1.
出版信息
J Org Chem. 2007 Mar 2;72(5):1856-8. doi: 10.1021/jo062483g. Epub 2007 Jan 31.
We report herein a simple, scalable, transition-metal-free approach to the synthesis of alpha-aryl methyl ketones from diazonium tetrafluoroborate salts under mild conditions. This methodology uses easily accessible and nontoxic starting material and was applied to the multi-kilogram-scale preparation of 1-(3-bromo-4-methylphenyl)propan-2-one.
我们在此报告一种简单、可扩展、无过渡金属的方法，用于在温和条件下由四氟硼酸重氮盐合成α-芳基甲基酮。该方法使用易于获得且无毒的起始原料，并应用于1-(3-溴-4-甲基苯基)丙-2-酮的多千克规模制备。
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