孕中期羊水瘦素和胰岛素水平与随后的妊娠期糖尿病
Midtrimester amniotic fluid leptin and insulin levels and subsequent gestational diabetes.
作者信息
D'Anna Rosario, Baviera Giovanni, Cannata Maria L, De Vivo Antonio, Di Benedetto Antonino, Corrado Francesco
机构信息
Department of Obstetrics and Gynecology, University of Messina, Messina, Italy.
出版信息
Gynecol Obstet Invest. 2007;64(2):65-8. doi: 10.1159/000099149. Epub 2007 Jan 30.
AIMS
To evaluate midtrimester amniotic fluid leptin levels in pregnancies subsequently complicated by gestational diabetes.
METHODS
We studied 32 pregnant women with gestational diabetes and a control group of 43 normal pregnancies with an adequate gestational age fetus. All underwent a midtrimester amniocentesis: leptin and insulin were measured in the amniotic fluid. Data were compared with the Mann-Whitney U-test.
RESULTS
Median leptin concentrations in the amniotic fluid of the gestational diabetes mellitus patients were significantly higher than in the control group (15.1 vs. 7.9 ng/ml) (p = 0.001); amniotic insulin concentrations were also higher in the gestational diabetes mellitus than in the control group (0.67 vs. 0.38 microU/ml) (p = 0.02). Furthermore, amniotic fluid leptin levels were directly correlated with amniotic insulin concentrations; instead, there was no correlation with maternal BMI and birth weight.
CONCLUSION
Our data suggest that in pregnancies subsequently complicated by gestational diabetes, amniotic fluid leptin and insulin levels are higher in the early fetal period.
目的
评估妊娠中期羊水中瘦素水平，这些妊娠随后并发妊娠期糖尿病。
方法
我们研究了32例患有妊娠期糖尿病的孕妇以及一个由43例具有合适孕周胎儿的正常妊娠组成的对照组。所有孕妇均在妊娠中期接受了羊膜腔穿刺术：测量羊水中的瘦素和胰岛素。数据采用曼-惠特尼U检验进行比较。
结果
妊娠期糖尿病患者羊水中瘦素浓度中位数显著高于对照组（15.1对7.9 ng/ml）（p = 0.001）；妊娠期糖尿病患者羊水中胰岛素浓度也高于对照组（0.67对0.38 μU/ml）（p = 0.02）。此外，羊水瘦素水平与羊水胰岛素浓度直接相关；相反，与孕妇体重指数和出生体重无关。
结论
我们的数据表明，在随后并发妊娠期糖尿病的妊娠中，胎儿早期羊水中瘦素和胰岛素水平较高。
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