通过狄尔斯-阿尔德/逆狄尔斯-阿尔德串联反应高效一锅法不对称合成联芳基化合物。

An efficient one-pot asymmetric synthesis of biaryl compounds via Diels-Alder/retro-Diels-Alder cascade reactions.

作者信息

Liu Yongxiang, Lu Kui, Dai Mingji, Wang Kai, Wu Wanqing, Chen Jiahua, Quan Junmin, Yang Zhen

机构信息

Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education and Beijing National Laboratory for Molecular Science (BNLMS), College of Chemistry, Laboratory of Chemical Genomics, Shenzhen Graduate School, China.

出版信息

Org Lett. 2007 Mar 1;9(5):805-8. doi: 10.1021/ol063013b. Epub 2007 Feb 1.

DOI:10.1021/ol063013b

PMID:17266319

Abstract

[reaction: see text] A single-step chirality transfer method for the synthesis of axially chiral biaryl compounds by construction of the second aromatic ring via a Diels-Alder/retro-Diels-Alder cascade reaction is reported. This methodology should find broad application in the synthesis of natural products and asymmetric catalysts.

摘要

[反应：见正文] 报道了一种通过狄尔斯-阿尔德/逆狄尔斯-阿尔德串联反应构建第二个芳环来合成轴手性联芳基化合物的单步手性转移方法。该方法在天然产物和不对称催化剂的合成中应具有广泛的应用。