犬乳腺肿瘤中循环血管内皮生长因子的临床意义
Clinical significance of circulating vascular endothelial growth factor in dogs with mammary gland tumors.
作者信息
Kato Yuka, Asano Kazushi, Mogi Toshiaki, Kutara Kenji, Teshima Kenji, Edamura Kazuya, Tsumagari Shigehisa, Hasegawa Atsuhiko, Tanaka Shigeo
机构信息
Laboratory of Veterinary Surgery, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, Fujisawa, Kanagawa, Japan.
出版信息
J Vet Med Sci. 2007 Jan;69(1):77-80. doi: 10.1292/jvms.69.77.
Increase in circulating vascular endothelial growth factor (VEGF) is suggested as a prognostic indicator in human patients with malignant tumors. The purpose of this study was to evaluate the clinical significance of circulating VEGF in dogs with mammary gland tumors (MGT). Both plasma and serum VEGF were significantly higher in dogs with MGT when compared with those in the healthy dogs. In dogs with MGT, the plasma and serum VEGF of the malignant group increased significantly compared with those of the benign group. Additionally, there was a significant difference between the plasma and serum VEGF in the groups with postoperative metastasis and no metastasis. Circulating VEGF is expected to be clinically available for the determination of prognosis in canine MGT.
循环血管内皮生长因子（VEGF）水平升高被认为是人类恶性肿瘤患者的一个预后指标。本研究的目的是评估循环VEGF在患有乳腺肿瘤（MGT）的犬中的临床意义。与健康犬相比，患有MGT的犬的血浆和血清VEGF均显著更高。在患有MGT的犬中，恶性组的血浆和血清VEGF与良性组相比显著升高。此外，术后有转移和无转移的组之间血浆和血清VEGF存在显著差异。循环VEGF有望在临床上用于确定犬MGT的预后。
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