内镜鼻窦手术后透明质酸钠与羧甲基纤维素钠混合溶液的抗粘连作用
Antiadhesive effect of the mixed solution of sodium hyaluronate and sodium carboxymethylcellulose after endoscopic sinus surgery.
作者信息
Kim Jeong Hong, Lee Joo-Hwan, Yoon Joo-heon, Chang Jung Hyun, Bae Jung Ho, Kim Kyung-Su
机构信息
Department of Otorhinolaryngology, Brain Korea 21 Project for Medical Science, Seoul, South Korea.
出版信息
Am J Rhinol. 2007 Jan-Feb;21(1):95-9. doi: 10.2500/ajr.2007.21.2911.
BACKGROUND
We evaluated the clinical efficacy and safety of the mixed solution of sodium hyaluronate and sodium carboxymethylcellulose (HA-CMC) for prevention of adhesion after endoscopic sinus surgery.
METHODS
Preoperative computed tomography (CT) scans were graded. At the completion of surgery, HA-CMC was applied to Merocel and repeatedly applied after the removal of Merocel. As a control, normal saline was applied. Endoscopic examination was performed postoperatively and grading was done.
RESULTS
The rate of adhesion was the highest at 2 weeks postoperatively and was significantly lower in the HA-CMC-treated group than the control on all postoperative days. The grouping of cases by CT scores at 2 weeks postoperatively showed lower adhesion formation with the HA-CMC treatment than the control. The safety profile of the patients was normal at 4 weeks postoperatively.
CONCLUSION
HA-CMC is an efficacious and safe material in decreasing the incidence of adhesion after endoscopic sinus surgery.
背景
我们评估了透明质酸钠和羧甲基纤维素钠（HA-CMC）混合溶液预防鼻内镜鼻窦手术后粘连的临床疗效和安全性。
方法
对术前计算机断层扫描（CT）进行分级。手术结束时，将HA-CMC应用于美罗培南，并在移除美罗培南后重复应用。作为对照，应用生理盐水。术后进行内镜检查并分级。
结果
粘连率在术后2周时最高，在所有术后天数中，HA-CMC治疗组的粘连率均显著低于对照组。术后2周按CT评分对病例进行分组显示，HA-CMC治疗组的粘连形成低于对照组。术后4周患者的安全性概况正常。
结论
HA-CMC是一种有效且安全的材料，可降低鼻内镜鼻窦手术后粘连的发生率。
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