Kim Jeong Hong, Lee Joo-Hwan, Yoon Joo-heon, Chang Jung Hyun, Bae Jung Ho, Kim Kyung-Su
Department of Otorhinolaryngology, Brain Korea 21 Project for Medical Science, Seoul, South Korea.
Am J Rhinol. 2007 Jan-Feb;21(1):95-9. doi: 10.2500/ajr.2007.21.2911.
We evaluated the clinical efficacy and safety of the mixed solution of sodium hyaluronate and sodium carboxymethylcellulose (HA-CMC) for prevention of adhesion after endoscopic sinus surgery.
Preoperative computed tomography (CT) scans were graded. At the completion of surgery, HA-CMC was applied to Merocel and repeatedly applied after the removal of Merocel. As a control, normal saline was applied. Endoscopic examination was performed postoperatively and grading was done.
The rate of adhesion was the highest at 2 weeks postoperatively and was significantly lower in the HA-CMC-treated group than the control on all postoperative days. The grouping of cases by CT scores at 2 weeks postoperatively showed lower adhesion formation with the HA-CMC treatment than the control. The safety profile of the patients was normal at 4 weeks postoperatively.
HA-CMC is an efficacious and safe material in decreasing the incidence of adhesion after endoscopic sinus surgery.
我们评估了透明质酸钠和羧甲基纤维素钠（HA-CMC）混合溶液预防鼻内镜鼻窦手术后粘连的临床疗效和安全性。
对术前计算机断层扫描（CT）进行分级。手术结束时，将HA-CMC应用于美罗培南，并在移除美罗培南后重复应用。作为对照，应用生理盐水。术后进行内镜检查并分级。
粘连率在术后2周时最高，在所有术后天数中，HA-CMC治疗组的粘连率均显著低于对照组。术后2周按CT评分对病例进行分组显示，HA-CMC治疗组的粘连形成低于对照组。术后4周患者的安全性概况正常。
HA-CMC是一种有效且安全的材料，可降低鼻内镜鼻窦手术后粘连的发生率。
