胺碘酮在伊布利特未能恢复窦性心律后的近期发作房颤中的作用。
The role of amiodarone in recent-onset atrial fibrillation after ibutilide has failed to restore sinus rhythm.
作者信息
Sideris S, Bonios M, Melexopoulou C, Exarchos P, Tsatiris K, Kogias J
机构信息
Cardiology Department, General Hospital of Karditsa, Karditsa, Greece.
出版信息
Cardiology. 2007;107(4):399-401. doi: 10.1159/000099059. Epub 2007 Feb 6.
BACKGROUND
Ibutilide is a class III antiarrhythmic drug that is used for the cardioversion of atrial arrhythmias, but it can cause torsades de pointes. Amiodarone is also used for the cardioversion of atrial fibrillation and prolongs the QT interval but rarely causes torsades de pointes.
METHODS AND RESULTS
The study included 51 consecutive patients with recent onset atrial fibrillation in whom the administration of ibutilide failed to restore sinus rhythm. In those patients we decided to proceed to intravenous administration of amiodarone. The QT intervals were measured on 12-lead ECG. After 11 +/- 5 h of the administration of the amiodarone, 42 patients (82%) were on sinus rhythm. There was no episode of non-sustained torsades de pointes or hypotension that followed the administration of the two antiarrhythmic agents.
CONCLUSIONS
The administration of amiodarone in the case of ibutilide failure may be a useful adjunct to current cardioversion protocols for recent onset atrial fibrillation.
背景
伊布利特是一种III类抗心律失常药物，用于心房性心律失常的复律，但它可引起尖端扭转型室速。胺碘酮也用于心房颤动的复律，可延长QT间期，但很少引起尖端扭转型室速。
方法与结果
该研究纳入了51例近期发生心房颤动且伊布利特复律失败的连续患者。在这些患者中，我们决定继续静脉给予胺碘酮。通过12导联心电图测量QT间期。在给予胺碘酮11±5小时后，42例患者（82%）恢复窦性心律。在给予这两种抗心律失常药物后，未发生非持续性尖端扭转型室速或低血压事件。
结论
在伊布利特复律失败的情况下给予胺碘酮，可能是目前近期发生心房颤动复律方案的一种有用辅助手段。
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