Revill P, Moral M A, Prous J R
Medical Information Department, Prous Science, Barcelona, Spain.
Drugs Today (Barc). 2006 Dec;42(12):785-90. doi: 10.1358/dot.2006.42.12.1032059.
There is a growing interest in possible links between impaired insulin signaling and the pathogenesis of Alzheimer's disease. Insulin and insulin-signaling mechanisms are important for neuronal survival, and central nervous system neurodegeneration is associated with dysfunctional neuronal insulin receptors. This short review focuses on recent findings that many important components of Alzheimer's disease appear to stem from imbalances in insulin signaling intrinsic to the brain, rather than systemic insulin imbalances, and that treatments aimed at redressing insulin imbalances in the brain could be effective therapies.
胰岛素信号受损与阿尔茨海默病发病机制之间可能存在的联系正受到越来越多的关注。胰岛素和胰岛素信号传导机制对神经元存活至关重要，而中枢神经系统神经退行性变与神经元胰岛素受体功能失调有关。这篇简短的综述聚焦于近期的研究发现，即阿尔茨海默病的许多重要组成部分似乎源于大脑内在的胰岛素信号失衡，而非全身性胰岛素失衡，并且旨在纠正大脑胰岛素失衡的治疗方法可能是有效的疗法。
