Yamaguchi Masakazu, Shibata Osamu, Saito Masataka, Yoshimura Maki, Nishioka Kenji, Makita Tetsuji, Sumikawa Koji
Department of Anesthesiology, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan.
J Anesth. 2007;21(1):37-41. doi: 10.1007/s00540-006-0447-0. Epub 2007 Jan 30.
ATP causes airway smooth-muscle contraction in patients with asthma and chronic obstructive pulmonary disease. Propofol and ketamine attenuate the airway smooth-muscle contraction induced by histamine and acetylcholine. However, it is not clear whether propofol and ketamine affect the ATP-induced airway smooth-muscle contraction.
We examined the effects of propofol and ketamine on the ATP-induced contraction and ATP-P(2)-purinoceptor binding.
Propofol attenuated the ATP-induced contraction in a dose-dependent manner, with a 50% inhibitory concentration of 54 +/- 22 microM. Ketamine at 300 microM attenuated the ATP-induced contraction. In the binding study, propofol attenuated the binding of the P(2)-purinoceptor with [(3)H]-ATP in a dose-dependent manner, while ketamine did not attenuate this binding.
Propofol attenuates ATP-induced contraction through the inhibition of ATP-P(2)-purinoceptor binding.
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