[Study on the association between the HLA-DRB1 alleles and type 2 diabetes in Yi nationality of Yunnan].
作者信息
Yang Hong-ying, Xue Li, Xu Mian, Ren Chun-feng, Yuan Hui-yun, Tai Wen-lin, Yang Yu, He Wei
机构信息
The Clinical Laboratory, the Second Affiliated Hospital, Kunming Medical College, Kunming, Yunnan, 650101 PR China.
出版信息
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2007 Feb;24(1):101-3.
OBJECTIVE
To investigate the association between the polymorphism of HLA-DRB1 alleles and type 2 diabetes mellitus in Yi nationality of Yunnan.
METHODS
Polymerase chain reaction-sequence specific primers (PCR-SSP) genotyping method was conducted in 79 patients with type 2 diabetes mellitus and 47 ethnically matched controls in Yi Nationality Autonomous Prefecture, Chuxiong.
RESULTS
HLA-DR7 and DR11 allele frequencies in type 2 diabetic mellitus patients were significantly higher than those in non-diabetic control subjects respectively(P is 0.009, RR is 8.329;P is 0.029, RR is 7.734).
CONCLUSION
DR7 and DR11 alleles are probably susceptible genes of type 2 diabetes mellitus in Yunnan Yi nationality.
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