Armbruster H, Vetter W, Uhlschmid G, Zaruba K, Beckerhoff B, Nussberger J, Vetter H, Siegenthaler W
Proc Eur Dial Transplant Assoc. 1975;11:268-76.
In normal supine man, a marked circadian rhythm was found in plasma renin activity (PRA) and in plasma aldosterone concentration, with highest levels in the morning and lowest in the evening. Short-term suppression of ACTH by dexamethasone did not eliminate the circadian variation of plasma aldosterone. In patients with a transplanted and thus denervated kidney, no such rhythm of PRA could be observed. From our data it is suggested that the normal circadian rhythm of PRA depends on intact renal innervation and is controlled by the central nervous system.
在正常仰卧位的男性中，发现血浆肾素活性（PRA）和血浆醛固酮浓度存在明显的昼夜节律，早晨水平最高，晚上最低。地塞米松对促肾上腺皮质激素（ACTH）的短期抑制并未消除血浆醛固酮的昼夜变化。在肾移植因而神经支配已去除的患者中，未观察到PRA的这种节律。根据我们的数据表明，PRA的正常昼夜节律取决于完整的肾神经支配，并受中枢神经系统控制。
