来自通脱木花、髓、叶和果实的齐墩果烷型三萜类化合物。

Oleanane-type triterpenes from the flowers, pith, leaves, and fruit of Tetrapanax papyriferus.

作者信息

Ho Jiau-Ching, Chen Chiu-Ming, Row Lie-Ching

机构信息

Department of Chemical and Materials Engineering, Ta Hwa Institute of Technology, Chung-Lin, Hsinchu, 307 Taiwan, ROC.

出版信息

Phytochemistry. 2007 Mar;68(5):631-5. doi: 10.1016/j.phytochem.2006.10.007. Epub 2007 Feb 7.

DOI:10.1016/j.phytochem.2006.10.007

PMID:17289094

Abstract

Four oleanane-type triterpenes, 3alpha,21beta,22alpha-trihydroxy-11,13(18)-oleanadien-28-oic acid (1), 3-epi-papyriogenin C (2), 21-O-acetyl-21-hydroxy-3-oxo-11,13(18)-oleanadien-28-oic acid (3) and 3beta-hydroxy-21-oxo-11,13(18)-oleanadien-28-oic acid methyl ester (4), together with four known triterpenes, were isolated from Tetrapanax papyriferus (Hook) K. Koch. Papyriogenin A (8) exhibited anti-HIV activity and low cytotoxicity in acutely infected H9 lymphocytes. Their structures were determined by analysis of spectroscopic data, including by 1D and 2D NMR.

摘要

从通脱木（Tetrapanax papyriferus (Hook) K. Koch）中分离得到了四种齐墩果烷型三萜化合物，即3α,21β,22α-三羟基-11,13(18)-齐墩果二烯-28-酸（1）、3-表-纸莎草素C（2）、21-O-乙酰基-21-羟基-3-氧代-11,13(18)-齐墩果二烯-28-酸（3）和3β-羟基-21-氧代-11,13(18)-齐墩果二烯-28-酸甲酯（4），以及四种已知的三萜化合物。纸莎草素A（8）在急性感染的H9淋巴细胞中表现出抗HIV活性和低细胞毒性。它们的结构通过光谱数据分析确定，包括一维和二维核磁共振。