Zhou Weilie, Gao Peng, Shao Lei, Caruntu Daniela, Yu Minghui, Chen Jianfeng, O'Connor Charles J
Advanced Materials Research Institute, University of New Orleans, New Orleans, Louisiana 70148, USA.
Nanomedicine. 2005 Sep;1(3):233-7. doi: 10.1016/j.nano.2005.06.005.
Magnetic, hollow silica nanocomposites (MHSNC), including nanospheres and nanotubes, have been successfully synthesized using a coating of Fe(3)O(4) magnetic nanoparticles (NPs) ( approximately 10 nm) and silica on nanosized spherical and nanoneedle-like calcium carbonate (CaCO(3)) surfaces under alkaline conditions. The nanosized CaCO(3) surfaces were used as nanotemplates, and tetraethoxysilane and magnetic NPs were used as precursors. The as-synthesized MHSNC were immersed in an acidic solution to remove the CaCO(3), forming magnetic, hollow silica nanospheres and nanotubes. The MHSNC were characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), x-ray powder diffraction, and superconducting quantum interference device (SQUID) magnetometer. SEM and TEM results showed that a smooth surface of MHSNC and a thin layer of silica ( approximately 10 nm) embedded with the magnetic NPs were successfully formed, and that the CaCO(3) nanotemplates appeared to be dissolved. SQUID measurement demonstrated that magnetization of MHSNC was dependent on temperature, exhibiting superparamagnetism. The MHSNC were immersed in ibuprofen solution. The amount of the loaded drug was determined to be 12 wt% for nanospheres, and 8 wt% for nanotubes by UV measurement, respectively. Drug-loaded MHSNC have potential applications in nanomedicine.
磁性中空二氧化硅纳米复合材料（MHSNC），包括纳米球和纳米管，已在碱性条件下通过在纳米尺寸的球形和纳米针状碳酸钙（CaCO₃）表面包覆Fe₃O₄磁性纳米颗粒（NPs）（约10纳米）和二氧化硅成功合成。纳米尺寸的CaCO₃表面用作纳米模板，四乙氧基硅烷和磁性NPs用作前驱体。将合成后的MHSNC浸入酸性溶液中以去除CaCO₃，从而形成磁性中空二氧化硅纳米球和纳米管。通过扫描电子显微镜（SEM）、透射电子显微镜（TEM）、X射线粉末衍射和超导量子干涉装置（SQUID）磁力计对MHSNC进行了表征。SEM和TEM结果表明，成功形成了表面光滑的MHSNC以及嵌入磁性NPs的二氧化硅薄层（约10纳米），并且CaCO₃纳米模板似乎已溶解。SQUID测量表明，MHSNC的磁化强度取决于温度，表现出超顺磁性。将MHSNC浸入布洛芬溶液中。通过紫外测量确定，纳米球的载药量为12 wt%，纳米管的载药量为8 wt%。载药MHSNC在纳米医学中有潜在应用。
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