叔氨基酸作为PPARα/γ双重激动剂的发现-I。

Discovery of tertiary aminoacids as dual PPARalpha/gamma agonists-I.

作者信息

Devasthale Pratik V, Chen Sean, Jeon Yoon, Qu Fucheng, Ryono Denis E, Wang Wei, Zhang Hao, Cheng Lin, Farrelly Dennis, Golla Rajasree, Grover Gary, Ma Zhengping, Moore Lisa, Seethala Ramakrishna, Sun Wei, Doweyko Arthur M, Chandrasena Gamini, Sleph Paul, Hariharan Narayanan, Cheng Peter T W

机构信息

Discovery Chemistry, Bristol-Myers Squibb Pharmaceutical Research Institute, PO Box 5400, Princeton, NJ 08543-5400, USA.

出版信息

Bioorg Med Chem Lett. 2007 Apr 15;17(8):2312-6. doi: 10.1016/j.bmcl.2007.01.060. Epub 2007 Jan 25.

DOI:10.1016/j.bmcl.2007.01.060

PMID:17292606

Abstract

A novel series of potent dual agonists of PPARalpha and PPARgamma, the alkoxybenzylglycines, was identified and explored using a solution-phase library approach. The synthesis and structure-activity relationships of this series of dual PPARalpha/gamma agonists are described.

摘要

使用溶液相库方法鉴定并研究了一系列新型的强效PPARα和PPARγ双重激动剂，即烷氧基苄基甘氨酸。描述了该系列双重PPARα/γ激动剂的合成及构效关系。