[促肾上腺皮质激素释放激素对其自身1型受体在人胎盘中的作用]
[Action of corticotropin-releasing hormone on its own receptor type-1 in human placenta].
作者信息
Wang Xiao-dong, Yu Hai-yan, He Mao-mao, Liu Shu-yun
机构信息
Department of Obstetrics and Gynecology, West China Second Hospital, Sichuan University, Chengdu 610041, China.
出版信息
Sichuan Da Xue Xue Bao Yi Xue Ban. 2007 Jan;38(1):101-4.
OBJECTIVE
To investigate the expression of corticotropin-releasing hormone and its receptor type-1 in human placental tissues during caesarian operations.
METHODS
IHC-SP staining and ISH methods were adopted to identify the expression patterns of CRH and its receptor CRH-R1 in the placenta taken from the women who had uncomplicated pregnancies. The placental tissues were collected after caesarian operations on the women with threatened labor.
RESULTS
Positive expressions of both CRH and CRH-R1 messenger ribonucleic acid and peptide were found in the placental tissues, but the later was stronger (P<0.05).
CONCLUSION
The elevated level of placental CRH may be a trigger of the transcription of its own receptor CRH-R1 during caesarian operations. This positive feedback of CRH on its own receptor may represent a functional adaptation of human utero-plcental-fetal unit in responding to stress.
目的
研究剖宫产术中促肾上腺皮质激素释放激素及其1型受体在人胎盘组织中的表达情况。
方法
采用免疫组织化学SP法和原位杂交法，对妊娠情况正常的产妇胎盘组织中促肾上腺皮质激素释放激素（CRH）及其受体CRH-R1的表达模式进行鉴定。对有先兆临产的产妇行剖宫产术后收集胎盘组织。
结果
胎盘组织中CRH及其受体CRH-R1的信使核糖核酸及肽均呈阳性表达，但后者更强（P<0.05）。
结论
剖宫产术中胎盘CRH水平升高可能是其自身受体CRH-R1转录的触发因素。CRH对其自身受体的这种正反馈可能代表了人子宫-胎盘-胎儿单位对应激反应的一种功能适应性。
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