CRF 01_AE型HIV-1感染所致痴呆患者的神经心理学异常
Neuropsychological abnormalities in patients with dementia in CRF 01_AE HIV-1 infection.
作者信息
Valcour V G, Sithinamsuwan P, Nidhinandana S, Thitivichianlert S, Ratto-Kim S, Apateerapong W, Shiramizu B T, Desouza M S, Chitpatima S T, Watt G, Chuenchitra T, Robertson K R, Paul R H, McArthur J C, Kim J H, Shikuma C M
机构信息
Hawaii AIDS Clinical Research Program, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, USA.
出版信息
Neurology. 2007 Feb 13;68(7):525-7. doi: 10.1212/01.wnl.0000253196.78193.c7.
HIV-associated dementia (HAD) is not firmly established in patients with circulating recombinant form (CRF) 01_AE HIV-1. In this study, we compared neuropsychological performance among 15 Thai individuals with HAD, 15 Thai individuals without HAD, and 30 HIV-negative control subjects. HIV-1 participants were highly active anti-retroviral therapy naive and matched by age, education, and CD4 count. Neuropsychological testing abnormalities were identified in most cognitive domains among HAD vs HIV-negative participants, confirming the presence of HAD in CRF01_AE.
在具有循环重组形式（CRF）01_AE HIV-1的患者中，与HIV相关的痴呆（HAD）尚未得到确凿证实。在本研究中，我们比较了15名患有HAD的泰国人、15名未患HAD的泰国人和30名HIV阴性对照受试者的神经心理表现。HIV-1参与者均未接受过高效抗逆转录病毒治疗，且在年龄、教育程度和CD4细胞计数方面相匹配。与HIV阴性参与者相比，HAD患者在大多数认知领域均发现神经心理测试异常，证实了CRF01_AE中存在HAD。
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